Terajima Masanori, Co Mary Dawn T, Cruz John, Ennis Francis A
Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester.
J Infect Dis. 2015 Oct 1;212(7):1052-60. doi: 10.1093/infdis/jiv181. Epub 2015 Mar 20.
Human influenza is a highly contagious acute respiratory illness that is responsible for significant morbidity and excess mortality worldwide. In addition to neutralizing antibodies, there are antibodies that bind to influenza virus-infected cells and mediate lysis of the infected cells by natural killer (NK) cells (antibody-dependent cellular cytotoxicity [ADCC]) or complement (complement-dependent lysis [CDL]). We analyzed sera obtained from 16 healthy adults (18-63 years of age), 52 children (2-17 years of age), and 10 infants (0.75-1 year of age) in the United States, who were unlikely to have been exposed to the avian H7N9 subtype of influenza A virus, by ADCC and CDL assays. As expected, none of these sera had detectable levels of hemagglutination-inhibiting antibodies against the H7N9 virus, but we unexpectedly found high titers of ADCC antibodies to the H7N9 subtype virus in all sera from adults and children aged ≥8 years.
人感染流感是一种高度传染性的急性呼吸道疾病，在全球范围内导致了显著的发病率和额外死亡率。除了中和抗体外，还有一些抗体可与感染流感病毒的细胞结合，并通过自然杀伤（NK）细胞介导感染细胞的裂解（抗体依赖性细胞毒性[ADCC]）或补体（补体依赖性裂解[CDL]）。我们通过ADCC和CDL试验分析了来自美国16名健康成年人（18 - 63岁）、52名儿童（2 - 17岁）和10名婴儿（0.75 - 1岁）的血清，这些人不太可能接触过甲型禽流感H7N9亚型病毒。正如预期的那样，这些血清中均未检测到针对H7N9病毒的血凝抑制抗体水平，但我们意外地发现，在所有8岁及以上成年人和儿童的血清中，针对H7N9亚型病毒的ADCC抗体滴度很高。
