Javadi Leila, Pourghassem Gargari Bahram, Salekzamani Shabnam, Yousefzadeh Rana
Department of Nutrition, Nutrition Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Nutrition Research Center, Department of Biochemistry and Diet Therapy, School of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran.
Acta Med Iran. 2015;53(3):162-7.
The association between Helicobacter pylori (HP) infection and concentration of folate or homocysteine are still unclear. The aim of the present study was to assess the effect of HP infection on folate and homocysteine concentrations in patients infected with HP and healthy participants. We also assessed dietary intakes of folate, vitamins B6 and B12 in two groups. In this case-control study, 44 participants with HP-infection and 46 healthy controls were studied. Participants were recruited from those referred to the central laboratory of Tabriz University of Medical Sciences. Blood samples were collected to determine serum folate and homocysteine levels. The presence of both IgG and IgA in serum was considered as HP positive. Dietary intakes were assessed in all participants by 24-hour dietary recalls by trained interviewers for three days. The mean concentration of serum folate was significantly lower in HP-positive patients than in controls (8.49 nmol/L vs. 10.95 nmol/L, respectively; P=0.01). Although the mean concentration of serum homocysteine differed between groups, statistical significance was missed (HP infected patients: 9.35 µmol/L; healthy participants: 8.96 µmol/L; P=0.064). Macro- and micronutrient intakes showed no significant difference between participants with and without HP infection. In logistic regression models, there was a negative correlation between folate concentration and HP infection even after controlling for confounding factors (OR=0.82; CI95%=0.79-0.97). In this study, authors showed that a negative association presents between HP infection and serum folate concentrations, but the homocysteine status was not differed significantly between HP-positive and HP-negative participants.
幽门螺杆菌（HP）感染与叶酸或同型半胱氨酸浓度之间的关联仍不明确。本研究的目的是评估HP感染对HP感染患者和健康参与者叶酸及同型半胱氨酸浓度的影响。我们还评估了两组人群叶酸、维生素B6和维生素B12的膳食摄入量。在这项病例对照研究中，对44名HP感染参与者和46名健康对照者进行了研究。参与者招募自转诊至大不里士医科大学中心实验室的人群。采集血样以测定血清叶酸和同型半胱氨酸水平。血清中IgG和IgA均存在被视为HP阳性。由经过培训的访谈员通过连续三天的24小时膳食回顾来评估所有参与者的膳食摄入量。HP阳性患者血清叶酸的平均浓度显著低于对照组（分别为8.49 nmol/L和10.95 nmol/L；P = 0.01）。尽管两组血清同型半胱氨酸的平均浓度有所差异，但未达到统计学显著性（HP感染患者：9.35 µmol/L；健康参与者：8.96 µmol/L；P = 0.064）。宏量营养素和微量营养素的摄入量在有和没有HP感染的参与者之间没有显著差异。在逻辑回归模型中，即使在控制混杂因素后，叶酸浓度与HP感染之间仍存在负相关（OR = 0.82；CI95% = 0.79 - 0.97）。在本研究中，作者表明HP感染与血清叶酸浓度之间存在负相关，但HP阳性和HP阴性参与者之间的同型半胱氨酸状态没有显著差异。
