Stettin D, Waldmann A, Ströhle A, Hahn A
Leibniz University Hannover, Nutrition Physiology and Human Nutrition Unit, Institute of Food Science, Hannover, Germany.
Adv Med Sci. 2008;53(2):205-13. doi: 10.2478/v10039-008-0050-8.
Some investigations, but not all, found that a chronic infection with Helicobacter pylori (Hp) is associated with deficiencies in B vitamins, elevated plasma total homocysteine concentrations (tHcy) and increased plasma levels of proinflammatory acute-phase proteins. It has been suggested that these factors promote atherogenesis and therefore could mechanistically explain why people infected with Hp might have an increased risk for cardiovascular diseases (CVD). Therefore we evaluated the association between Hp-infection, concentration of C-reactive protein (CRP), and status of various B vitamins in apparently healthy subjects.
In 69 subjects with proved Hp-infection and 21 healthy control subjects identified in a cross sectional study, blood samples were collected to determine serum folate, serum vitamin B12, serum methylmalonic acid (MMA), serum CRP and plasma vitamin B6 and plasma total homocysteine (tHcy).
The mean concentration of CRP was significantly higher in the Hp-positive collective than in controls. Although mean concentrations of vitamin B12, B6, and MMA differed between the groups, statistical significance was missed. However, the mean concentrations of homocysteine and folic acid were nearly the same in both groups. In univariate analysis a significant impact of Hp-status was shown on cobalamin (p=0.028; eta square: 0.055), and in multivariate analysis of variance the Hp-status had an impact on vitamin B12-values (p=0.028; eta square 0.057).
In this study Hp-infection shows no significant impact on status of B vitamins, but has a significant influence on CRP concentration. However, this study does not support the hypothesis that Hp-infection is related to CVD via elevated levels of tHcy.
一些（而非全部）研究发现，幽门螺杆菌（Hp）慢性感染与B族维生素缺乏、血浆总同型半胱氨酸浓度（tHcy）升高以及促炎急性期蛋白的血浆水平增加有关。有人提出，这些因素会促进动脉粥样硬化的发生，因此从机制上可以解释为什么感染Hp的人患心血管疾病（CVD）的风险可能会增加。因此，我们评估了表面健康的受试者中Hp感染、C反应蛋白（CRP）浓度与各种B族维生素状态之间的关联。
在一项横断面研究中确定的69名经证实的Hp感染受试者和21名健康对照受试者中，采集血样以测定血清叶酸、血清维生素B12、血清甲基丙二酸（MMA）、血清CRP以及血浆维生素B6和血浆总同型半胱氨酸（tHcy）。
Hp阳性组的CRP平均浓度显著高于对照组。尽管两组之间维生素B12、B6和MMA的平均浓度有所不同，但未达到统计学显著性。然而，两组的同型半胱氨酸和叶酸平均浓度几乎相同。在单变量分析中，Hp状态对钴胺素显示出显著影响（p = 0.028；偏 eta 平方：0.055），在多变量方差分析中，Hp状态对维生素B12值有影响（p = 0.028；偏 eta 平方0.057）。
在本研究中，Hp感染对B族维生素状态没有显著影响，但对CRP浓度有显著影响。然而，本研究并不支持Hp感染通过tHcy水平升高与CVD相关的假说。
