Yeung Timothy Pok Chi, Bauman Glenn, Yartsev Slav, Fainardi Enrico, Macdonald David, Lee Ting-Yim
Department of Medical Biophysics, The University of Western Ontario, 1151 Richmond Street N., London, Ontario, Canada N6A 5C1; London Regional Cancer Program, London Health Sciences Centre, 790 Commissioners Road East, London, ON, Canada N6A 5W9; Robarts Research Institute, The University of Western Ontario, 1151 Richmond St. N., London, Ontario, Canada N6A 5B7.
Department of Medical Biophysics, The University of Western Ontario, 1151 Richmond Street N., London, Ontario, Canada N6A 5C1; London Regional Cancer Program, London Health Sciences Centre, 790 Commissioners Road East, London, ON, Canada N6A 5W9; Department of Oncology, The University of Western Ontario, Victoria Hospital, London Health Sciences Centre, 790 Commissioners Road East, London, Ontario, Canada N6A 4L6.
Eur J Radiol. 2015 Dec;84(12):2386-92. doi: 10.1016/j.ejrad.2015.02.012. Epub 2015 Feb 23.
Dynamic perfusion CT (PCT) is an imaging technique for assessing the vascular supply and hemodynamics of brain tumors by measuring blood flow, blood volume, and permeability-surface area product. These PCT parameters provide information complementary to histopathologic assessments and have been used for grading brain tumors, distinguishing high-grade gliomas from other brain lesions, differentiating true progression from post-treatment effects, and predicting prognosis after treatments. In this review, the basic principles of PCT are described, and applications of PCT of brain tumors are discussed. The advantages and current challenges, along with possible solutions, of PCT are presented.
动态灌注CT（PCT）是一种成像技术，通过测量血流量、血容量和通透性-表面积乘积来评估脑肿瘤的血管供应和血流动力学。这些PCT参数提供了与组织病理学评估互补的信息，并已用于脑肿瘤分级、将高级别胶质瘤与其他脑病变区分开来、区分真正的进展与治疗后效应以及预测治疗后的预后。在本综述中，描述了PCT的基本原理，并讨论了脑肿瘤PCT的应用。介绍了PCT的优点、当前挑战以及可能的解决方案。
