Housey G M, Kirschmeier P, Garte S J, Burns F, Troll W, Weinstein I B
Biochem Biophys Res Commun. 1985 Feb 28;127(1):391-8. doi: 10.1016/s0006-291x(85)80172-8.
RNA sequences homologous to the Long Terminal Repeat (LTR) sequence of Moloney Murine Leukemia Virus proviral DNA are expressed in murine squamous cell carcinomas of the skin induced by chemical carcinogens. These transcripts range in size from 8.2 to less than 2.4 kb but their size profile varies between individual tumors. These RNAs are not detected in the poly A+ RNA fraction obtained from the epidermis of control mice or carcinogen induced skin papillomas. The poly A+ RNAs from the livers and spleens of some of the mice with skin carcinomas also revealed LTR related sequences, whereas these RNAs were not detected in the livers and spleens of control mice or of carcinogen-treated mice that did not develop carcinomas. Thus, chemical carcinogenesis in mouse skin is associated with constitutive expression of endogenous retrovirus related sequences in the carcinomas as well as in certain apparently normal host tissues.
与莫洛尼鼠白血病病毒前病毒DNA的长末端重复序列（LTR）同源的RNA序列，在化学致癌物诱导的小鼠皮肤鳞状细胞癌中表达。这些转录本的大小范围从8.2kb到小于2.4kb，但它们的大小分布在不同肿瘤之间有所不同。在从对照小鼠的表皮或致癌物诱导的皮肤乳头瘤中获得的聚腺苷酸加尾（poly A+）RNA组分中未检测到这些RNA。一些患有皮肤癌的小鼠的肝脏和脾脏中的聚腺苷酸加尾RNA也显示出与LTR相关的序列，而在对照小鼠或未发生癌症的致癌物处理小鼠的肝脏和脾脏中未检测到这些RNA。因此，小鼠皮肤中的化学致癌作用与癌组织以及某些明显正常的宿主组织中内源性逆转录病毒相关序列的组成型表达有关。
