“肥胖与骨代谢：运动诱导肥胖青少年体重减轻的影响”（ADIBOX）项目的横断面和纵向研究方案

Cross-sectional and longitudinal study protocols of the 'ADIposity and BOne metabolism: effects of eXercise-induced weight loss in obese adolescents' (ADIBOX) project.

作者信息

Chaplais Elodie, Dutheil Frédéric, Naughton Geraldine, Greene David, Pereira Bruno, Thivel David, Courteix Daniel

机构信息

Laboratory of the Metabolic Adaptations to Exercise under Physiological and Pathological Conditions (AME2P), Clermont University, Blaise Pascal University, Clermont-Ferrand, France.

School of Exercise Science, Australian Catholic University, Strathfield, New South Wales, Australia.

出版信息

BMJ Open. 2016 Oct 18;6(10):e011407. doi: 10.1136/bmjopen-2016-011407.

DOI:10.1136/bmjopen-2016-011407

PMID:27797988

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5073595/

Abstract

INTRODUCTION

A need exists for sustainable and clinically effective weight management interventions, suitable for preventing well-linked chronic disease such as diabetes and cardiovascular disease and some less investigated secondary conditions such as bone alteration. The ADIposity and BOne metabolism: effects of eXercise-induced weight loss in obese adolescents (ADIBOX) protocol was designed to provide a better understanding of the interaction between adipokines and bone hormones in adolescents with obesity and how a 10-month physical activity programme may affect these interactions.

METHODS AND ANALYSIS

The ADIBOX protocol combines 2 studies. The first study involves a total of 68 adolescents aged 12-16 years. This cross-sectional study will include both males and females (1:1 ratio), either living with obesity/overweight (n=34; body mass index (BMI) ≤97th centile and ≥85th centile) or normal weight (n=34; BMI<85th centile). The second study is a longitudinal study that will include 50 obese adolescent girls and track them over a period of 42 weeks. Weight loss programme will consist of a combination of physical activity and a normocaloric diet. Bone and adiposity-related measurements will be performed every 14 weeks. Both studies will assess participants' anthropometric profile, nutrition and physical activity, body composition, bone densitometry and blood markers of bone, growth and adiposity.

ETHICS AND DISSEMINATION

The ADIBOX protocol complies with the ethics guidelines for clinical research and has been approved by their respective ethics committee (Australian Catholic University Committee Ethic, Australia and Hospital Sud Est 1 committee, France). Findings from this protocol are expected to clarify the possible interactions between adiposity and bone in childhood obesity and will be disseminated at several research conferences and published articles in peer-reviewed journals.

TRIAL REGISTRATION NUMBER

NCT02626273; Pre-results.

摘要

引言

需要可持续且临床有效的体重管理干预措施，以预防诸如糖尿病和心血管疾病等密切相关的慢性病，以及一些较少研究的继发性病症，如骨骼改变。肥胖与骨代谢：运动诱导肥胖青少年体重减轻的影响（ADIBOX）方案旨在更好地了解肥胖青少年中脂肪因子与骨激素之间的相互作用，以及为期10个月的体育活动计划如何影响这些相互作用。

方法与分析

ADIBOX方案结合了两项研究。第一项研究共涉及68名12至16岁的青少年。这项横断面研究将包括男性和女性（比例为1:1），他们要么患有肥胖/超重（n = 34；体重指数（BMI）≤第97百分位数且≥第85百分位数），要么体重正常（n = 34；BMI<第85百分位数）。第二项研究是一项纵向研究，将包括50名肥胖少女，并对她们进行为期42周的跟踪。减肥计划将包括体育活动和正常热量饮食的组合。每14周进行一次与骨骼和肥胖相关的测量。两项研究都将评估参与者的人体测量学特征、营养和体育活动、身体成分、骨密度测定以及骨骼、生长和肥胖的血液标志物。