膜不对称性对脂质双层膜力学性质影响的测量。
Measurements of the effect of membrane asymmetry on the mechanical properties of lipid bilayers.
作者信息
Elani Yuval, Purushothaman Sowmya, Booth Paula J, Seddon John M, Brooks Nicholas J, Law Robert V, Ces Oscar
机构信息
Department of Chemistry, Imperial College London, Exhibition Road, London, SW7 2AZ, UK.
出版信息
Chem Commun (Camb). 2015 Apr 25;51(32):6976-9. doi: 10.1039/c5cc00712g. Epub 2015 Mar 23.
We detail an approach for constructing asymmetric membranes and characterising their mechanical properties, leading to the first measurement of the effect of asymmetry on lipid bilayer mechanics. Our results demonstrate that asymmetry induces a significant increase in rigidity compared to symmetric membranes. Given that all biological membranes are asymmetric our findings have profound implications for the role of this phenomenon in biology.
我们详细介绍了一种构建不对称膜并表征其力学性能的方法，从而首次测量了不对称性对脂质双分子层力学的影响。我们的结果表明，与对称膜相比，不对称性会导致刚性显著增加。鉴于所有生物膜都是不对称的，我们的发现对这一现象在生物学中的作用具有深远意义。
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