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肌萎缩侧索硬化症中的异常体感诱发电位。

Abnormal somatosensory evoked potentials in amyotrophic lateral sclerosis.

作者信息

Dasheiff R M, Drake M E, Brendle A, Erwin C W

出版信息

Electroencephalogr Clin Neurophysiol. 1985 Apr;60(4):306-11. doi: 10.1016/0013-4694(85)90004-5.

DOI:10.1016/0013-4694(85)90004-5
PMID:2579797
Abstract

A patient with typical clinical and electromyographic features of amyotrophic lateral sclerosis (ALS) was found to have abnormal somatosensory evoked potentials (SEPs). Evoked responses are generally considered to be normal in ALS despite occasional pathological and clinical evidence of sensory involvement. Thus, abnormal SEPs are considered to argue against a diagnosis of ALS. Based on the present case and a review of the literature, we suggest that abnormal SEPs need not exclude a diagnosis of ALS.

摘要

一名具有肌萎缩侧索硬化症(ALS)典型临床和肌电图特征的患者被发现体感诱发电位(SEP)异常。尽管偶尔有感觉受累的病理和临床证据,但在ALS中诱发电位通常被认为是正常的。因此,SEP异常被认为与ALS的诊断相悖。基于本病例及文献回顾,我们认为SEP异常并不排除ALS的诊断。

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Marked changes in dendritic structure and spine density precede significant neuronal death in vulnerable cortical pyramidal neuron populations in the SOD1(G93A) mouse model of amyotrophic lateral sclerosis.在肌萎缩侧索硬化症的 SOD1(G93A)小鼠模型中,易损皮质锥体神经元群体中树突结构和棘密度的明显变化先于显著的神经元死亡。
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