Thompson Corinne N, Phan My V T, Hoang Nguyen Van Minh, Minh Pham Van, Vinh Nguyen Thanh, Thuy Cao Thu, Nga Tran Thi Thu, Rabaa Maia A, Duy Pham Thanh, Dung Tran Thi Ngoc, Phat Voong Vinh, Nga Tran Vu Thieu, Tu Le Thi Phuong, Tuyen Ha Thanh, Yoshihara Keisuke, Jenkins Claire, Duong Vu Thuy, Phuc Hoang Le, Tuyet Pham Thi Ngoc, Ngoc Nguyen Minh, Vinh Ha, Chinh Nguyen Tran, Thuong Tang Chi, Tuan Ha Manh, Hien Tran Tinh, Campbell James I, Chau Nguyen Van Vinh, Thwaites Guy, Baker Stephen
The Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam; Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, Oxford University, United Kingdom; The London School of Hygiene and Tropical Medicine, London, United Kingdom; The Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom; Centre for Immunity, Infection and Evolution, University of Edinburgh, Edinburgh, United Kingdom; The Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan; Gastrointestinal Bacteria Reference Unit, Public Health England, London, United Kingdom; Children's Hospital 1, Ho Chi Minh City, Vietnam; Children's Hospital 2, Ho Chi Minh City, Vietnam; Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam.
The Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam; Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, Oxford University, United Kingdom; The London School of Hygiene and Tropical Medicine, London, United Kingdom; The Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom; Centre for Immunity, Infection and Evolution, University of Edinburgh, Edinburgh, United Kingdom; The Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan; Gastrointestinal Bacteria Reference Unit, Public Health England, London, United Kingdom; Children's Hospital 1, Ho Chi Minh City, Vietnam; Children's Hospital 2, Ho Chi Minh City, Vietnam; Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
Am J Trop Med Hyg. 2015 May;92(5):1045-52. doi: 10.4269/ajtmh.14-0655. Epub 2015 Mar 23.
We performed a prospective multicenter study to address the lack of data on the etiology, clinical and demographic features of hospitalized pediatric diarrhea in Ho Chi Minh City (HCMC), Vietnam. Over 2,000 (1,419 symptomatic and 609 non-diarrheal control) children were enrolled in three hospitals over a 1-year period in 2009-2010. Aiming to detect a panel of pathogens, we identified a known diarrheal pathogen in stool samples from 1,067/1,419 (75.2%) children with diarrhea and from 81/609 (13.3%) children without diarrhea. Rotavirus predominated in the symptomatic children (664/1,419; 46.8%), followed by norovirus (293/1,419; 20.6%). The bacterial pathogens Salmonella, Campylobacter, and Shigella were cumulatively isolated from 204/1,419 (14.4%) diarrheal children and exhibited extensive antimicrobial resistance, most notably to fluoroquinolones and third-generation cephalosporins. We suggest renewed efforts in generation and implementation of policies to control the sale and prescription of antimicrobials to curb bacterial resistance and advise consideration of a subsidized rotavirus vaccination policy to limit the morbidity due to diarrheal disease in Vietnam.
我们开展了一项前瞻性多中心研究，以解决越南胡志明市住院儿童腹泻病因、临床及人口统计学特征方面数据匮乏的问题。在2009年至2010年的1年时间里，三家医院共纳入了2000多名儿童（1419名有症状腹泻儿童和609名无腹泻对照儿童）。为了检测一系列病原体，我们在1419名腹泻儿童中的1067名（75.2%）以及609名无腹泻儿童中的81名（13.3%）的粪便样本中鉴定出了一种已知的腹泻病原体。轮状病毒在有症状儿童中占主导（1419名中的664名；46.8%），其次是诺如病毒（1419名中的293名；20.6%）。沙门氏菌、弯曲杆菌和志贺氏菌这几种细菌病原体累计从1419名腹泻儿童中的204名（14.4%）分离得到，且表现出广泛的抗菌药物耐药性，最显著的是对氟喹诺酮类和第三代头孢菌素耐药。我们建议重新努力制定和实施相关政策，以控制抗菌药物的销售和处方，从而遏制细菌耐药性，并建议考虑实施一项补贴轮状病毒疫苗接种政策，以降低越南腹泻病的发病率。
