• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

早期小鼠胚胎发育过程中长重复ETn序列转录本的空间分布。

Spatial distribution of transcripts of the long repeated ETn sequence during early mouse embryogenesis.

作者信息

Brûlet P, Condamine H, Jacob F

出版信息

Proc Natl Acad Sci U S A. 1985 Apr;82(7):2054-8. doi: 10.1073/pnas.82.7.2054.

DOI:10.1073/pnas.82.7.2054
PMID:2580305
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC397490/
Abstract

RNA X DNA in situ hybridization revealed a high level of ETn ("early transposon") transcripts in the pluripotent cell lineage of the 3.5- to 7.5-day mouse embryo. Some extra-embryonic ectoderm derivatives also show a high level of ETn transcripts at these stages. Older embryos (8.5 days and later) have a uniform low level of ETn transcripts.

摘要

RNA与DNA原位杂交显示，在3.5至7.5天大的小鼠胚胎的多能细胞谱系中，ETn（“早期转座子”）转录本水平很高。在这些阶段，一些胚外外胚层衍生物也显示出高水平的ETn转录本。较老的胚胎（8.5天及以后）ETn转录本水平均一较低。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b36b/397490/de2c3e57b5e5/pnas00347-0195-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b36b/397490/7e88bb56fb20/pnas00347-0193-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b36b/397490/dbc8fb5e9962/pnas00347-0194-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b36b/397490/28e6facdf7a8/pnas00347-0194-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b36b/397490/3333676042d1/pnas00347-0195-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b36b/397490/de2c3e57b5e5/pnas00347-0195-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b36b/397490/7e88bb56fb20/pnas00347-0193-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b36b/397490/dbc8fb5e9962/pnas00347-0194-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b36b/397490/28e6facdf7a8/pnas00347-0194-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b36b/397490/3333676042d1/pnas00347-0195-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b36b/397490/de2c3e57b5e5/pnas00347-0195-b.jpg

相似文献

1
Spatial distribution of transcripts of the long repeated ETn sequence during early mouse embryogenesis.早期小鼠胚胎发育过程中长重复ETn序列转录本的空间分布。
Proc Natl Acad Sci U S A. 1985 Apr;82(7):2054-8. doi: 10.1073/pnas.82.7.2054.
2
RNAs containing B2 repeated sequences are transcribed in the early stages of mouse embryogenesis.含有B2重复序列的RNA在小鼠胚胎发育的早期阶段被转录。
EMBO J. 1985 Jul;4(7):1749-53. doi: 10.1002/j.1460-2075.1985.tb03846.x.
3
Integration of the transposon-like element ETn upstream of V lambda 2 in the cell line P3X63Ag8.
J Immunol. 1989 Oct 1;143(7):2384-8.
4
Structure and genomic organization of a new family of murine retrovirus-related DNA sequences (MuRRS).一种新的小鼠逆转录病毒相关DNA序列家族（MuRRS）的结构与基因组组织
Nucleic Acids Res. 1985 May 24;13(10):3461-70. doi: 10.1093/nar/13.10.3461.
5
Selective transcription of genomic sequences common to both N- and X-tropic endogenous retroviruses in BALB/c mouse tissues.BALB/c小鼠组织中N-嗜性和X-嗜性内源性逆转录病毒共有的基因组序列的选择性转录。
J Gen Virol. 1979 Jun;43(3):723-8. doi: 10.1099/0022-1317-43-3-723.
6
Three-dimensional fluorescence in situ hybridization in mouse embryos using repetitive probe sequences.
Methods Mol Biol. 2010;659:401-8. doi: 10.1007/978-1-60761-789-1_31.
7
Variations in hybridization of RNA from different mouse tissues and embryos to endogenous C-type virus DNA transcripts.来自不同小鼠组织和胚胎的RNA与内源性C型病毒DNA转录本杂交的差异。
J Gen Virol. 1975 Jul;28(1):129-35. doi: 10.1099/0022-1317-28-1-129.
8
Isolation of cDNA including a reverse transcriptase-like sequence transcribed from the long interspersed repetitive DNA sequence of rat.从大鼠长散在重复DNA序列转录的包含类逆转录酶序列的cDNA的分离。
Agric Biol Chem. 1991 Oct;55(10):2475-8.
9
Identification of a retrovirus-like repetitive element in human DNA.人类DNA中一种逆转录病毒样重复元件的鉴定。
Proc Natl Acad Sci U S A. 1984 Dec;81(23):7510-4. doi: 10.1073/pnas.81.23.7510.
10
[Characteristics of the gene transcription of the intracisternal A-particles].[脑内A颗粒的基因转录特征]
Vopr Virusol. 1984 May-Jun;29(3):345-50.

引用本文的文献

1
Enhancer adoption by an LTR retrotransposon generates viral-like particles, causing developmental limb phenotypes.长末端重复序列（LTR）逆转座子对增强子的采用会产生病毒样颗粒，导致肢体发育表型。
Nat Genet. 2025 Jul 9. doi: 10.1038/s41588-025-02248-5.
2
Expression of LINE-1 elements is required for preimplantation development and totipotency.LINE-1元件的表达是着床前发育和全能性所必需的。
Genes Dis. 2025 Feb 7;12(5):101555. doi: 10.1016/j.gendis.2025.101555. eCollection 2025 Sep.
3
Endogenous Retroviruses Walk a Fine Line between Priming and Silencing.

本文引用的文献

1
An improved in situ hybridization method for the detection of cellular RNAs in Drosophila tissue sections and its application for localizing transcripts of the homeotic Antennapedia gene complex.一种改良的原位杂交方法，用于检测果蝇组织切片中的细胞 RNA，及其在定位同源异形 Antennapedia 基因复合物转录本中的应用。
EMBO J. 1983;2(4):617-23. doi: 10.1002/j.1460-2075.1983.tb01472.x.
2
Structure, variation and synthesis of retrovirus long terminal repeat.逆转录病毒长末端重复序列的结构、变异与合成
Cell. 1981 Nov;27(1 Pt 2):1-3. doi: 10.1016/0092-8674(81)90353-6.
3
Establishment in culture of pluripotential cells from mouse embryos.
内源性逆转录病毒在启动和沉默之间走钢丝。
Viruses. 2020 Jul 23;12(8):792. doi: 10.3390/v12080792.
4
Mouse germ line mutations due to retrotransposon insertions.由于逆转座子插入导致的小鼠种系突变。
Mob DNA. 2019 Apr 13;10:15. doi: 10.1186/s13100-019-0157-4. eCollection 2019.
5
Switching of dominant retrotransposon silencing strategies from posttranscriptional to transcriptional mechanisms during male germ-cell development in mice.在小鼠雄性生殖细胞发育过程中，主要逆转录转座子沉默策略从转录后机制向转录机制的转变。
PLoS Genet. 2017 Jul 27;13(7):e1006926. doi: 10.1371/journal.pgen.1006926. eCollection 2017 Jul.
6
Friend or Foe: Epigenetic Regulation of Retrotransposons in Mammalian Oogenesis and Early Development.敌友之间：哺乳动物卵子发生和早期发育中逆转录转座子的表观遗传调控
Yale J Biol Med. 2016 Dec 23;89(4):487-497. eCollection 2016 Dec.
7
Transposable elements at the center of the crossroads between embryogenesis, embryonic stem cells, reprogramming, and long non-coding RNAs.转座元件处于胚胎发生、胚胎干细胞、重编程和长链非编码RNA之间的交叉路口中心。
Sci Bull (Beijing). 2015;60(20):1722-1733. doi: 10.1007/s11434-015-0905-x. Epub 2015 Oct 13.
8
Retroviral transcriptional regulation and embryonic stem cells: war and peace.逆转录病毒转录调控与胚胎干细胞：战争与和平
Mol Cell Biol. 2015 Mar;35(5):770-7. doi: 10.1128/MCB.01293-14. Epub 2014 Dec 29.
9
Regulation of Mouse Retroelement MuERV-L/MERVL Expression by REX1 and Epigenetic Control of Stem Cell Potency.REX1对小鼠反转录元件MuERV-L/MERVL表达的调控及干细胞潜能的表观遗传控制
Front Oncol. 2014 Feb 6;4:14. doi: 10.3389/fonc.2014.00014. eCollection 2014.
10
A novel intergenic ETnII-β insertion mutation causes multiple malformations in polypodia mice.一个新的基因间 ETnII-β 插入突变导致多趾鼠的多种畸形。
PLoS Genet. 2013;9(12):e1003967. doi: 10.1371/journal.pgen.1003967. Epub 2013 Dec 5.
从小鼠胚胎中建立多能细胞的培养方法。
Nature. 1981 Jul 9;292(5819):154-6. doi: 10.1038/292154a0.
4
Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells.从在由畸胎癌干细胞条件培养液中培养的早期小鼠胚胎中分离出多能细胞系。
Proc Natl Acad Sci U S A. 1981 Dec;78(12):7634-8. doi: 10.1073/pnas.78.12.7634.
5
Amounts, synthesis, and some properties of intracisternal A particle-related RNA in early mouse embryos.小鼠早期胚胎中与脑池内A颗粒相关的RNA的含量、合成及一些特性
Proc Natl Acad Sci U S A. 1984 Jan;81(2):488-92. doi: 10.1073/pnas.81.2.488.
6
Early differential tissue expression of transposon-like repetitive DNA sequences of the mouse.小鼠转座子样重复DNA序列的早期差异组织表达
Proc Natl Acad Sci U S A. 1983 Sep;80(18):5641-5. doi: 10.1073/pnas.80.18.5641.
7
Improved method for cloning DNA complementary to minor mRNAs: preparation of a hybridization probe from purified mRNAs encoding intermediate filament proteins.克隆与稀有mRNA互补的DNA的改良方法：从编码中间丝蛋白的纯化mRNA制备杂交探针。
Gene. 1983 Apr;22(1):59-68. doi: 10.1016/0378-1119(83)90064-1.
8
Repetitive sequence transcripts in development.
Nature. 1982 Jun 24;297(5868):633-5. doi: 10.1038/297633a0.
9
Form and function of retroviral proviruses.逆转录病毒前病毒的形式与功能。
Science. 1982 May 21;216(4548):812-20. doi: 10.1126/science.6177038.
10
Storage of two-cell mouse embryos in vitro.体外保存二细胞期小鼠胚胎。
Aust J Biol Sci. 1969 Aug;22(4):1065-8. doi: 10.1071/bi9691065.