Radiation Oncology Department, Virgen de las Nieves University Hospital, Granada, Spain; San Cecilio University Hospital, Instituto de Investigación Biosanitaria ibs. Granada, University of Granada, CIBERESP, Spain.
Center of Urgent Medical Assistance of Tunis, Laboratory of Toxicology and Environment (LR12SP07), Montfleury, Tunis 1008, Tunisia.
Sci Total Environ. 2015 Jul 1;520:106-13. doi: 10.1016/j.scitotenv.2015.03.045. Epub 2015 Mar 22.
The aim of this study was to investigate the association between serum concentrations of a group of organochlorine pesticides/polychlorinated biphenyls with xenoestrogenic potential and the risk of breast cancer in a female population from Tunisia. The relationship between serum levels of the pollutants and the risk of cancer was assessed using logistic regression analyses. In the unadjusted models, β-hexachlorocyclohexane (β-HCH), hexachlorobenzene, heptachlor, polychlorinated biphenyl congeners 138, 153, and 180, and p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE) were positively associated with breast cancer risk. However, when the models were further adjusted for the selected covariates, only β-HCH and p,p'-DDE remained statistically significant, and heptachlor was borderline significant. In addition, analyses using POP concentration tertiles corroborated a positive dose-response relationship that was significant for p,p'-DDE (p-trend=0.020) and borderline significant for heptachlor (p-trend=0.078). A similar trend was also confirmed for β-HCH, in which concentrations≥limit of detection were positively associated with breast cancer risk (vs. concentrations<limit of detection, OR=3.44, p<0.05). Finally, the relative influence of each chemical in the presence of the others was assessed by entering the three chemicals in a single model with all covariates, and only β-HCH remained positively associated with the risk of cancer (OR:1.18, 95%CI: 1.05-1.34). Our findings suggest a potential association between exposure to at least one organochlorine pesticide and breast cancer risk. However, our results should be interpreted with caution, and further research is warranted to confirm these findings.
本研究旨在探讨一组具有类雌激素活性的有机氯农药/多氯联苯（PCBs）血清浓度与突尼斯女性乳腺癌风险之间的关系。采用逻辑回归分析评估污染物血清水平与癌症风险之间的关系。在未调整的模型中，β-六氯环己烷（β-HCH）、六氯苯、七氯、多氯联苯同系物 138、153 和 180 以及对，对-二氯二苯二氯乙烯（p，p'-DDE）与乳腺癌风险呈正相关。然而，当模型进一步调整为选定的协变量时，只有 β-HCH 和 p，p'-DDE 仍具有统计学意义，而七氯则处于边缘显著水平。此外，使用 POP 浓度三分位数的分析证实了 p，p'-DDE（p-trend=0.020）和七氯（p-trend=0.078）呈阳性剂量反应关系。β-HCH 也证实了类似的趋势，其中浓度≥检测限与乳腺癌风险呈正相关（与浓度<检测限相比，OR=3.44，p<0.05）。最后，通过在包含所有协变量的单个模型中输入三种化学物质，评估每种化学物质在其他化学物质存在下的相对影响，只有 β-HCH 与癌症风险呈正相关（OR：1.18，95%CI：1.05-1.34）。我们的研究结果表明，接触至少一种有机氯农药与乳腺癌风险之间存在潜在关联。然而，我们的研究结果应谨慎解释，需要进一步研究来证实这些发现。
