Lazaryan Moran, Shasha-Zigelman Chen, Dagan Zachi, Berkovitch Matitiahu
Pharmacy Department, Assaf Harofeh Medical Center, Zerifin, Sackler School of Medicine -Tel Aviv University, Tel-Aviv, Israel.
Clinical Pharmacolo Unit, Assaf Harofeh Medical Center, Zerifin, Sackler School of Medicine -Tel Aviv University, Tel-Aviv, Israel.
Acta Paediatr. 2015 Jun;104(6):550-6. doi: 10.1111/apa.13012. Epub 2015 Apr 22.
Medical regulatory authorities, including the Food and Drug Administration and European Medicine Agency, have published restrictions regarding the use of codeine in paediatric patients and breastfeeding mothers. This review explored the various parameters that are involved in the metabolism and toxicology of codeine in these two populations.
The growing volume of data on potential serious adverse events and questionable efficacy indicates that codeine should not be prescribed for children under 12 years of age and breastfeeding mothers.
包括美国食品药品监督管理局和欧洲药品管理局在内的医学监管机构已发布了关于可待因在儿科患者和哺乳期母亲中使用的限制规定。本综述探讨了这两个人群中可待因代谢和毒理学所涉及的各种参数。
关于潜在严重不良事件和可疑疗效的数据越来越多，这表明不应为12岁以下儿童和哺乳期母亲开具可待因处方。
