哺乳期使用可待因的安全性：一位服用可待因的母亲所哺乳的新生儿发生致命性吗啡中毒
Safety of codeine during breastfeeding: fatal morphine poisoning in the breastfed neonate of a mother prescribed codeine.
作者信息
Madadi Parvaz, Koren Gideon, Cairns James, Chitayat David, Gaedigk Andrea, Leeder J Steven, Teitelbaum Ronni, Karaskov Tatyana, Aleksa Katarina
出版信息
Can Fam Physician. 2007 Jan;53(1):33-5.
Abstract
QUESTION
Recently a newborn died from morphine poisoning when his mother used codeine while breastfeeding. Many patients receive codeine for postlabour pain. Is it safe to prescribe codeine for nursing mothers?
ANSWER
When a mother is an ultrarapid metabolizer of cytochrome P450 2D6, she produces much more morphine when taking codeine than most people do. In this situation, newborns might be exposed to toxic levels of morphine when breastfeeding. Options to reduce this risk include discontinuing codeine after 2 to 3 days of use and being aware of symptoms of potential opioid toxicity in both mothers and newborns.
摘要
问题
最近有一名新生儿因母亲在母乳喂养期间使用可待因而死于吗啡中毒。许多患者在产后疼痛时会使用可待因。给哺乳期母亲开可待因是否安全？
答案
当母亲是细胞色素P450 2D6的超快代谢者时，她服用可待因时产生的吗啡比大多数人多得多。在这种情况下，新生儿在母乳喂养时可能会接触到有毒剂量的吗啡。降低这种风险的选择包括在使用2至3天后停用可待因，并留意母亲和新生儿潜在阿片类药物毒性的症状。
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