Chitrapriya Muthugounder Nalanaswamy, Rao Suresh Ranga, Lavu Vamsi
Department of Periodontology, Faculty of Dental Sciences, Sri Ramachandra University, Chennai, Tamil Nadu, India.
J Indian Soc Periodontol. 2015 Jan-Feb;19(1):14-7. doi: 10.4103/0972-124X.145798.
Chronic periodontitis is an inflammatory condition of the tooth supporting structures. There is increasing evidence that the cytokines interleukin-17 (IL-17) and interleukin-18 (IL-18) play a role in progression of chronic periodontitis.
The objective of this study was to compare the levels of the cytokines IL-17 and IL-18 in gingival tissue extracts from individuals with healthy gingiva, chronic gingivitis, and mild chronic periodontitis.
The study was performed in a hospital-based population with an experimental design.
A total of 69 individuals (n = 23 per group) were recruited for the study. Group 1 included 23 individuals with healthy gingiva and Group 2 included 23 chronic gingivitis patients and Group 3 included 23 patients with mild chronic periodontitis. Gingival tissues were collected during surgical procedures and levels of IL-17 and IL-18 were determined using enzyme-linked immunosorbent assay.
Intergroup comparison was done by posthoc Tukey's test.
The gingival tissue concentration of IL-17 was found to be highest in Group 2 (415.19 ± 76.84 pg/mg) followed by Group 3 (193.77 ± 37.32 pg/mg) and Group 1 (20.49 ± 6.05 pg/mg). Concentrations of IL-18 were significantly higher (P < 0.01) in Group 2 (1479.42 ± 330.33 pg/mg) when compared with Group 1 (385.18 ± 71.26 pg/mg) and Group 3 (330.24 ± 48.56 pg/mg).
There appears to be considerable variation of IL-17 and IL-18 levels in gingival tissue during periodontal health and disease.
慢性牙周炎是牙齿支持组织的一种炎症性疾病。越来越多的证据表明，细胞因子白细胞介素-17（IL-17）和白细胞介素-18（IL-18）在慢性牙周炎的进展中起作用。
本研究的目的是比较健康牙龈、慢性牙龈炎和轻度慢性牙周炎患者牙龈组织提取物中细胞因子IL-17和IL-18的水平。
该研究在以医院为基础的人群中进行，采用实验设计。
共招募69名个体（每组n = 23）进行研究。第1组包括23名健康牙龈个体，第2组包括23名慢性牙龈炎患者，第3组包括23名轻度慢性牙周炎患者。在手术过程中收集牙龈组织，并使用酶联免疫吸附测定法测定IL-17和IL-18的水平。
组间比较采用事后Tukey检验。
发现第2组牙龈组织中IL-17浓度最高（415.19±76.84 pg/mg），其次是第3组（193.77±37.32 pg/mg）和第1组（20.49±6.05 pg/mg）。与第1组（385.18±71.26 pg/mg）和第3组（330.24±48.56 pg/mg）相比，第2组IL-18浓度显著更高（P < 0.01）（1479.42±330.33 pg/mg）。
在牙周健康和疾病期间，牙龈组织中IL-17和IL-18水平似乎存在相当大的差异。
