Department of Periodontology, Pomeranian Medical University, 70-111 Szczecin, Poland.
Department of Prosthetics, Pomeranian Medical University, 70-111 Szczecin, Poland.
Int J Environ Res Public Health. 2021 Jan 26;18(3):1081. doi: 10.3390/ijerph18031081.
: Periodontitis (PD) is a chronic inflammatory disease that can eventually lead to tooth loss. Genetic and environmental factors such as smoking are involved in the pathogenesis of PD. The development of PD is potentiated by various pathogens that induce an immune response leading to the production of cytokines, such as interleukin (IL)-17. The synthesis of IL-17 is influenced genetically. The polymorphisms in gene may affect the synthesis of IL-17. The aim of this study was to examine the association between the rs763780 and rs2275913 polymorphisms and PD in non-smoking and smoking patients to check if these polymorphisms could be a risk factor for PD. : The study enrolled 200 patients with PD (130 non-smokers and 70 smokers) and 160 control subjects (126 non-smokers and 34 smokers). Periodontitis was diagnosed on the basis of 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. All samples were genotyped using allelic discrimination assays with TaqMan probes on a Real-Time PCR Detection System. : There were no statistically significant differences in the distribution of the rs763780 and rs2275913 genotypes and alleles between patients with PD and control subjects, between smoking patients with PD and smoking control subjects, and between non-smoking patients with PD and non-smoking control subjects. : The results of this study suggest a lack of statistically significant associations between rs763780 and rs2275913 polymorphisms and PD in Polish population.
牙周炎（PD）是一种慢性炎症性疾病，最终可能导致牙齿脱落。遗传和环境因素，如吸烟，参与了 PD 的发病机制。各种病原体的发展增强了 PD，这些病原体引起免疫反应，导致细胞因子如白细胞介素（IL）-17 的产生。IL-17 的合成受遗传影响。基因中的多态性可能影响 IL-17 的合成。本研究旨在研究非吸烟和吸烟患者中基因的 rs763780 和 rs2275913 多态性与 PD 之间的关联，以检查这些多态性是否是 PD 的危险因素。
该研究纳入了 200 名 PD 患者（130 名非吸烟者和 70 名吸烟者）和 160 名对照受试者（126 名非吸烟者和 34 名吸烟者）。牙周炎的诊断基于 2017 年世界牙周病和种植体周围疾病与条件分类研讨会。所有样本均使用 TaqMan 探针通过实时 PCR 检测系统上的等位基因鉴别分析进行基因分型。
PD 患者和对照组、PD 吸烟患者和吸烟对照组以及 PD 非吸烟患者和非吸烟对照组之间，rs763780 和 rs2275913 基因型和等位基因的分布无统计学差异。
本研究结果表明，波兰人群中 rs763780 和 rs2275913 多态性与 PD 之间缺乏统计学显著关联。
