Mohamed Heba A, Lake Benjamin R M, Laing Thomas, Phillips Roger M, Willans Charlotte E
School of Chemistry, University of Leeds, Woodhouse Lane, Leeds, LS2 9JT, UK.
Dalton Trans. 2015 Apr 28;44(16):7563-9. doi: 10.1039/c4dt03679d.
A new library of silver(I)-N-heterocyclic carbene complexes prepared from the natural products caffeine, theophylline and theobromine is reported. The complexes have been fully characterised using a combination of NMR spectroscopy, mass spectrometry, elemental analysis and X-ray diffraction analysis. Furthermore, the hydrophobicity of the complexes has been measured. The silver(I)-N-heterocyclic carbenes have been evaluated for their antiproliferative properties against a range of cancer cell lines of different histological types, and compared to cisplatin. The data shows different profiles of response when compared to cisplatin in the same panel of cells, indicating a different mechanism of action. Furthermore, it appears that the steric effect of the ligand and the hydrophobicity of the complex both play a role in the chemosensitivity of these compounds, with greater steric bulk and greater hydrophilicity delivering higher cytotoxicity.
报道了一个由天然产物咖啡因、茶碱和可可碱制备的新型银（I）-N-杂环卡宾配合物库。这些配合物已通过核磁共振光谱、质谱、元素分析和X射线衍射分析等多种方法进行了全面表征。此外，还测定了配合物的疏水性。对银（I）-N-杂环卡宾针对一系列不同组织学类型的癌细胞系的抗增殖特性进行了评估，并与顺铂进行了比较。数据显示，在同一组细胞中与顺铂相比时，有不同的反应情况，表明作用机制不同。此外，配体的空间效应和配合物的疏水性似乎都在这些化合物的化学敏感性中起作用，空间位阻越大和亲水性越强，细胞毒性越高。
