来自海兔（Aplysia depilans）的指状黑角二萜类化合物。

Dactylomelane diterpenes from the sea hare Aplysia depilans.

作者信息

Petraki Anastasia, Ioannou Efstathia, Papazafiri Panagiota, Roussis Vassilios

机构信息

†Department of Pharmacognosy and Chemistry of Natural Products, Faculty of Pharmacy, School of Health Sciences, University of Athens, Panepistimiopolis Zografou, Athens 15771, Greece.

‡Department of Animal and Human Physiology, Faculty of Biology, School of Science, University of Athens, Panepistimiopolis Zografou, Athens 15784, Greece.

出版信息

J Nat Prod. 2015 Mar 27;78(3):462-7. doi: 10.1021/np500851w. Epub 2015 Jan 20.

DOI:10.1021/np500851w

PMID:25814031

Abstract

A chemical investigation of the organic extract of the sea hare Aplysia depilans, collected off Skyros Island, Greece, yielded eight new brominated diterpenes (1-8), featuring the rare dactylomelane skeleton, together with the previously reported luzodiol (9). The structure elucidation and the assignment of the relative configurations of the new natural products were based on extensive NMR spectroscopic and MS spectrometric analyses. Compounds 1-9 were evaluated for their cytotoxic activities against five human tumor cell lines, but were proven inactive.

摘要

对采集于希腊斯基罗斯岛附近的海兔Aplysia depilans的有机提取物进行化学研究，得到了8个具有罕见指状黑环骨架的新溴代二萜（1-8），以及之前报道过的鲁佐二醇（9）。新天然产物的结构解析和相对构型的确定基于广泛的核磁共振光谱分析和质谱分析。对化合物1-9针对5种人类肿瘤细胞系的细胞毒性活性进行了评估，但结果显示它们没有活性。