Shen Ya-Ching, Lo Kuang-Liang, Kuo Yao-Haur, Kuo Yuh-Chi, Chen Chung-Hsiung, Khalil Ashraf T
School of Pharmacy, College of Medicine, National Taiwan University, Jen-Ai Road, Sec. 1, Taipei 100, Taiwan, Republic of China.
J Nat Prod. 2008 Dec;71(12):1993-7. doi: 10.1021/np8005327.
Chemical investigation of the soft coral Cespitularia hypotentaculata resulted in the isolation of six new diterpenes, cespihypotins Q-V. The new metabolites comprised five verticillane-type diterpenes and one nor-verticillane derivative. Their structures were determined through detailed spectroscopic analyses, especially HRESIMS and 2D NMR techniques. The relative configuration was deduced by interpretation of NOESY spectra. Cespihypotin T exhibited significant cytotoxic activity against human Daoy and WiDr tumor cell lines.
对软珊瑚低触手囊状软珊瑚进行化学研究，从中分离出6种新的二萜类化合物，即囊状低触手素Q - V。这些新的代谢产物包括5种轮状烷型二萜和1种降轮状烷衍生物。通过详细的光谱分析，尤其是高分辨电喷雾电离质谱（HRESIMS）和二维核磁共振（2D NMR）技术确定了它们的结构。通过对核Overhauser效应光谱（NOESY）的解析推导了相对构型。囊状低触手素T对人道氏瘤细胞系和维氏直肠癌细胞系表现出显著的细胞毒性活性。
