来自海兔Aplysia fasciata的代谢产物。

Metabolites from the sea hare Aplysia fasciata.

作者信息

Ioannou Efstathia, Nappo Michela, Avila Conxita, Vagias Constantinos, Roussis Vassilios

机构信息

Department of Pharmacognosy and Chemistry of Natural Products, School of Pharmacy, University of Athens, Panepistimiopolis Zografou, Athens, Greece.

出版信息

J Nat Prod. 2009 Sep;72(9):1716-9. doi: 10.1021/np900298a.

DOI:10.1021/np900298a

PMID:19694458

Abstract

Examination of the digestive and hermaphroditic glands' organic extract of the sea hare Aplysia fasciata yielded 16 metabolites, including eight sesquiterpenes, three diterpenes, and five C(15)-acetogenins. Among them, three sesquiterpenes, 6-hydroxy-1-brasilene (1), epibrasilenol acetate (2), and 6-epi-beta-snyderol (3), one acetogenin, (3Z,9Z)-7-chloro-6-hydroxy-12-oxo-pentadeca-3,9-dien-1-yne (4), and one diterpene, 16-acetoxy-15-bromo-7-hydroxy-9(11)-parguerene (5), are new natural products. The structure elucidation and the assignment of the relative configurations of the isolated natural products were established on the basis of extensive analyses of their spectroscopic data (NMR, MS, IR).

摘要

对海兔Aplysia fasciata的消化腺和两性腺有机提取物进行检测，得到了16种代谢产物，包括8种倍半萜、3种二萜和5种C(15)-产乙酸素。其中，3种倍半萜，即6-羟基-1-巴西烯（1）、乙酸表巴西烯醇酯（2）和6-表-β-斯奈德醇（3），1种产乙酸素，(3Z,9Z)-7-氯-6-羟基-12-氧代-十五碳-3,9-二烯-1-炔（4），以及1种二萜，16-乙酰氧基-15-溴-7-羟基-9(11)-帕尔盖烯（5），均为新的天然产物。通过对其光谱数据（核磁共振、质谱、红外光谱）的广泛分析，确定了分离出的天然产物的结构解析及其相对构型的归属。