Department of Rehabilitation Medicine and Institute of Wonkwang Medical Science, Wonkwang University School of Medicine, Iksan, Republic of Korea.
Biomed Res Int. 2018 Oct 4;2018:4619867. doi: 10.1155/2018/4619867. eCollection 2018.
The purpose of this study was to investigate the association of exercise capacity, cardiac function, and coronary artery calcification (CAC) with components of metabolic syndrome in Korean adults.
Medical records of healthy adults who underwent exercise tolerance test (ETT), coronary CT angiography (CTA), and echocardiography of the heart for cardiac health check-up were retrospectively reviewed. Patients who had a history of severe cardiovascular disease or could not perform ETT due to other musculoskeletal problems were excluded. Subjects were classified into groups based on the number of components for metabolic syndrome: no component (Group 1, n=90), 1, 2 components (Group 2, n=321), and 3 or more components (Group 3, n=154). Exercise capacity was assessed using the symptom-limited ETT, and CAC score was obtained using the coronary CTA and Agatston score. Cardiac structure and function were assessed using echocardiography.
A total of 565 patients (mean (SD) age 59.5 (9.1), 340 men, 225 women) were selected. Exercise capacity was significantly lower in Group 3 than in the other groups (p<0.05). The CAC score was significantly higher in Group 3 than in the other groups (p<0.05). Compared to the other groups, echocardiography findings in Group 3 showed a greater hypertrophy of the left ventricle and reduction in the diastolic function (p<0.05). Exercise capacity, CAC score, cardiac structure, and function were different between the 3 groups, where a tendency to worsen was observed from Group 1 to Group 3.
Metabolic syndrome decreases exercise capacity of the patient and contributes to CAC, thereby increasing the risk for cardiovascular diseases and deterioration in cardiac structure and function. Therefore, early detection of metabolic syndrome and subsequently the prevention and management of heart disease are necessary.
本研究旨在探讨韩国成年人运动能力、心功能和冠状动脉钙化（CAC）与代谢综合征各组分的关系。
回顾性分析了因心脏健康检查而行运动耐量试验（ETT）、冠状动脉 CT 血管造影（CTA）和心脏超声检查的健康成年人的病历。排除了有严重心血管疾病病史或因其他肌肉骨骼问题无法进行 ETT 的患者。根据代谢综合征的组分数量将受试者分为以下几组：无组分（组 1，n=90）、1 个组分（组 2，n=321）和 3 个或更多组分（组 3，n=154）。运动能力通过症状限制 ETT 评估，CAC 评分通过冠状动脉 CTA 和 Agatston 评分获得。心脏结构和功能通过超声心动图评估。
共纳入 565 例患者（平均（标准差）年龄 59.5（9.1）岁，340 例男性，225 例女性）。与其他两组相比，组 3 的运动能力明显较低（p<0.05）。与其他两组相比，组 3 的 CAC 评分明显较高（p<0.05）。与其他两组相比，组 3 的超声心动图检查结果显示左心室肥大程度更大，舒张功能降低（p<0.05）。三组之间运动能力、CAC 评分、心脏结构和功能均存在差异，组 1 到组 3 呈现出逐渐恶化的趋势。
代谢综合征降低了患者的运动能力，并导致 CAC 增加，从而增加了心血管疾病的风险，并导致心脏结构和功能恶化。因此，早期发现代谢综合征，并随后预防和管理心脏病是必要的。
