Gemryd P, Lundquist P G, Norberg L
Department of Otorhinolaryngology-Head and Neck Surgery, University Hospital, Linköping, Sweden.
Eur Arch Otorhinolaryngol. 1993;250(1):33-9. doi: 10.1007/BF00176946.
We have compared four different sialogogues and their degranulating effect on serous and mucous cells, and their long-term effects. From this and earlier experiments, even within the groups of alpha- and beta-adrenergic agents used, the effects varied on the serous and mucous cells. Previous studies have shown that cyclocytidine effectively degranulates serous cells without signs of cellular damage, while carbachol predominantly affects mucous acinar cells but gives early rise to permanent gland damage. Noradrenaline affects both serous and mucous cells, predominantly affecting serous cells with initial mitochondrial damage. Clonidine partially depletes both serous and mucous cells of their granules, producing permanent cellular damage. One month after a single injection of cyclocytidine the early findings described had disappeared. Carbachol showed permanent damage to salivary gland parenchyma, and both noradrenaline and clonidine demonstrated a long-term effect on acinar mucinous cells.
我们比较了四种不同的促唾液分泌剂及其对浆液性和黏液性细胞的脱颗粒作用以及它们的长期影响。从本次及之前的实验来看，即使在所用的α-和β-肾上腺素能药物组内，对浆液性和黏液性细胞的影响也各不相同。先前的研究表明，环胞苷可有效使浆液性细胞脱颗粒且无细胞损伤迹象，而卡巴胆碱主要影响黏液性腺泡细胞，但会较早导致永久性腺体损伤。去甲肾上腺素对浆液性和黏液性细胞均有影响，主要影响浆液性细胞并伴有初始线粒体损伤。可乐定可部分耗尽浆液性和黏液性细胞的颗粒，造成永久性细胞损伤。单次注射环胞苷一个月后，上述早期发现消失。卡巴胆碱对唾液腺实质显示出永久性损伤，而去甲肾上腺素和可乐定对腺泡黏液性细胞均表现出长期影响。
