Norberg L E, Abok K
Department of Otolaryngology, Linköping University Hospital, Sweden.
Arch Otorhinolaryngol. 1987;244(4):209-14. doi: 10.1007/BF00455307.
Rat submandibular glands were exposed to various sialagogues, including carbachol, clonidine, noradrenaline and cyclocytidine. The effects of these drugs were morphologically compared. Clonidine, which is an alpha-2-agonist, caused no depletion of granules in the serous cells examined. Noradrenaline and cyclocytidine, which are alpha-1-agonists, showed remarkable depletion of secretory granules in the serous cells. Carbachol caused visible and abundant salivation in the animals, but was found to produce only partial granular depletion of both serous and mucous cells. To induce experimentally a complete depletion of granular serous cells, cyclocytidine was found to be an excellent choice as a sialagogue with no side-effects on the cardiac and respiratory system.
将大鼠下颌下腺暴露于各种催涎剂，包括卡巴胆碱、可乐定、去甲肾上腺素和环胞苷。对这些药物的作用进行了形态学比较。作为α-2激动剂的可乐定，在所检查的浆液细胞中未导致颗粒耗竭。作为α-1激动剂的去甲肾上腺素和环胞苷，在浆液细胞中显示出明显的分泌颗粒耗竭。卡巴胆碱使动物出现明显且大量的流涎，但发现其仅导致浆液细胞和黏液细胞的颗粒部分耗竭。为了通过实验诱导颗粒性浆液细胞完全耗竭，发现环胞苷作为催涎剂是一个极佳选择，对心脏和呼吸系统无副作用。
