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新生儿皮下脂肪坏死——一例伴有典型并发症的非典型病例。

Subcutaneous fat necrosis of the newborn - An atypical case with typical complications.

作者信息

Lorenzo Cristina, Romana Andreia, Matias Joana, Calhau Paulo

机构信息

Department of Pediatrics Hospital de Santa Maria - Centro Hospitalar Universitário de Lisboa Norte, EPE Lisbon Portugal.

Department of Pediatrics Hospital Garcia de Orta, EPE Lisbon Portugal.

出版信息

Clin Case Rep. 2021 Feb 18;9(4):2069-2073. doi: 10.1002/ccr3.3945. eCollection 2021 Apr.

DOI:10.1002/ccr3.3945
PMID:33936641
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8077269/
Abstract

Subcutaneous fat necrosis of the newborn should be considered in newborns with suggestive skin lesions, even in the absence of perinatal distress. SCFN may cause long-standing complications, like hypertriglyceridemia or hypercalcemia. Hypercalcemia can be refractory to therapy and lead to poor weight gain and nephrocalcinosis, which should be closely monitored.

摘要

即使在没有围产期窘迫的情况下，对于有提示性皮肤病变的新生儿，也应考虑新生儿皮下脂肪坏死。新生儿皮下脂肪坏死可能会导致长期并发症，如高甘油三酯血症或高钙血症。高钙血症可能对治疗无效，并导致体重增加不佳和肾钙质沉着症，对此应密切监测。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a05/8077269/fb377f25cf3b/CCR3-9-2069-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a05/8077269/144f91d59e48/CCR3-9-2069-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a05/8077269/8ef0f2fc68c4/CCR3-9-2069-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a05/8077269/3551e6b93650/CCR3-9-2069-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a05/8077269/fb377f25cf3b/CCR3-9-2069-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a05/8077269/144f91d59e48/CCR3-9-2069-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a05/8077269/8ef0f2fc68c4/CCR3-9-2069-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a05/8077269/3551e6b93650/CCR3-9-2069-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a05/8077269/fb377f25cf3b/CCR3-9-2069-g005.jpg

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本文引用的文献

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Severe Thrombocytosis in a Newborn with Subcutaneous Fat Necrosis and Maternal Chorioamnionitis.患有皮下脂肪坏死和母体绒毛膜羊膜炎的新生儿严重血小板增多症。
Case Rep Hematol. 2020 Feb 21;2020:5742394. doi: 10.1155/2020/5742394. eCollection 2020.
2
Use of Zoledronic Acid in a Neonate with Subcutaneous Fat Necrosis Complicated with Severe, Refractory Hypercalcemia.唑来膦酸在新生儿皮下脂肪坏死并发严重、难治性高钙血症中的应用。
Am J Perinatol. 2019 Jul;36(S 02):S134-S138. doi: 10.1055/s-0039-1691777. Epub 2019 Jun 25.
3
Calcium management challenges in a macrosomic child with subcutaneous fat necrosis.
巨大儿合并皮下脂肪坏死的钙管理挑战
BMJ Case Rep. 2019 Feb 19;12(2):e227141. doi: 10.1136/bcr-2018-227141.
4
Subcutaneous fat necrosis of the newborn and associated hypercalcemia: A systematic review of the literature.新生儿皮下脂肪坏死及相关高钙血症：文献系统综述
Pediatr Dermatol. 2019 Jan;36(1):24-30. doi: 10.1111/pde.13640. Epub 2018 Sep 6.
5
Cutaneous complication of perinatal hypoxia.围产期缺氧的皮肤并发症。
Dermatol Online J. 2018 Mar 15;24(3):13030/qt076152vc.
6
Subcutaneous Fat Necrosis of the Newborn With Initial Hypocalcemia and Familial Recurrence: A Case Report.新生儿皮下脂肪坏死伴初发低钙血症和家族性复发：病例报告。
J Cutan Med Surg. 2018 Mar/Apr;22(2):223-225. doi: 10.1177/1203475417733459. Epub 2017 Sep 21.
7
Subcutaneous Fat Necrosis of the Newborn: Report of Five Cases.新生儿皮下脂肪坏死：5例报告
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8
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Acta Paediatr. 2016 Sep;105(9):e396-405. doi: 10.1111/apa.13463. Epub 2016 Jun 3.
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Arch Argent Pediatr. 2016 Feb;114(1):e13-6. doi: 10.5546/aap.2016.e13.
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