Lara Leire González, Villa Asunción Vicente, Rivas María Mercedes Otero, Capella Mariona Sunol, Prada Fredy, Enseñat María Antonia González
Dermatology Department, Hospital Sant Joan de Déu, Barcelona, Spain.
Dermatology Department, Hospital Sant Joan de Déu, Barcelona, Spain.
Pediatr Neonatol. 2017 Feb;58(1):85-88. doi: 10.1016/j.pedneo.2014.06.010. Epub 2014 Nov 26.
Subcutaneous fat necrosis of the newborn (SCFN) is a rare, self-limited disorder of the panniculus which appears in the first few weeks of life. SCFN generally follows an uncomplicated course. However, there are important complications for which the patient must be regularly monitored, including thrombocytopenia, hypoglycemia, hypertriglyceridemia, and most importantly, hypercalcemia. We report five infants with SCFN. All children were born at term. The onset of lesions was between 1 day and 20 days after birth. The back was the most frequent location. Birth hypoxia was the most frequent risk factor. Complications included hypercalcemia, hypoglycemia, and metastatic calcifications (disseminated subcutaneous calcifications, nephrocalcinosis, and myocardial calcifications). This study provides the first case of SCFN in the context of hypoxic encephalopathy and refractory septic shock that required extracorporeal membrane oxygenation (ECMO).
新生儿皮下脂肪坏死（SCFN）是一种罕见的、自限性的脂膜疾病，出现在出生后的头几周。SCFN通常病程简单。然而，有一些重要的并发症需要对患者进行定期监测，包括血小板减少、低血糖、高甘油三酯血症，最重要的是高钙血症。我们报告了5例SCFN患儿。所有患儿均足月出生。皮损出现于出生后1天至20天之间。背部是最常见的发病部位。出生时缺氧是最常见的危险因素。并发症包括高钙血症、低血糖和转移性钙化（弥漫性皮下钙化、肾钙质沉着症和心肌钙化）。本研究报道了首例在缺氧性脑病和难治性感染性休克背景下发生的需要体外膜肺氧合（ECMO）治疗的SCFN病例。
