Hennerici M, Hömberg V, Lange H W
Electroencephalogr Clin Neurophysiol. 1985 May;62(3):167-76. doi: 10.1016/0168-5597(85)90011-5.
Visual evoked potentials (VEPs) to full-field and half-field stimulation were recorded in a large sample of patients with Huntington's disease (n = 36) and subjects at risk (first-order offspring, n = 55) using a checkerboard pattern reversal stimulus. Whereas a clear diminution of the amplitudes found confirmed earlier findings in patients with Huntington's disease, further alterations of VEP wave forms consisted in the absence of asymmetric hemisphere lateralization to half-field stimulation (i) and severe distortion with amplification of the early NPN/PNP complexes (ii). Considering at least two different abnormal parameters necessary to represent a reliable indicator of the disease, 24 patients (67%) and 14 (25%) of the persons at risk exhibited pathological results. In contrast, only 2 among 36 patients (5%) but 30 (55%) among the offspring exhibited normal results. The diagnostic and predictive value of the investigation of VEPs in Huntington's disease is discussed.
使用棋盘格图案翻转刺激，在大量亨廷顿病患者（n = 36）和有患病风险的受试者（一级后代，n = 55）中记录了全视野和半视野刺激的视觉诱发电位（VEP）。虽然所发现的振幅明显降低证实了早期对亨廷顿病患者的研究结果，但VEP波形的进一步改变包括：（i）半视野刺激时缺乏不对称半球侧化；（ii）早期NPN/PNP复合波放大并严重畸变。考虑到至少需要两个不同的异常参数才能作为该疾病的可靠指标，24名患者（67%）和14名有患病风险者（25%）呈现出病理结果。相比之下，36名患者中只有2名（5%）结果正常，但后代中有30名（55%）结果正常。文中讨论了VEP检查在亨廷顿病中的诊断和预测价值。
