亨廷顿舞蹈症“高危”人群诱发电位与神经心理学检查结果的关系

Relationship between evoked potential and neuropsychological findings in persons "at risk" for Huntington's disease.

作者信息

Josiassen R C, Curry L M, Mancall E L, Shagass C, Roemer R A

出版信息

J Clin Exp Neuropsychol. 1986 Jan;8(1):21-36. doi: 10.1080/01688638608401294.

Abstract

Scalp-recorded evoked potentials (EPs) elicited by left and right median nerve stimulation (LSEP and RSEP), checkerboard pattern flash (VEP), and acoustic click (AEP) were obtained in 40 individuals "at risk" (AR) for Huntington's disease (HD) and 40 nonpatients matched for age, sex, and intelligence. EPs of AR subjects were generally similar to those of nonpatient's overall configuration; however, mean amplitudes were significantly lower for ARs. The lower amplitudes tended to occur primarily among a subgroup of ARs who manifested some degree of cognitive change, as defined by neuropsychological test criteria.

摘要

对40名有患亨廷顿舞蹈症（HD）“风险”（AR）的个体以及40名年龄、性别和智力相匹配的非患者，记录了头皮对左侧和右侧正中神经刺激（左体感诱发电位和右体感诱发电位）、棋盘格模式闪光（视觉诱发电位）以及听觉咔嗒声（听觉诱发电位）所诱发的诱发电位（EP）。有风险个体的诱发电位总体构型通常与非患者相似；然而，有风险个体的平均波幅显著更低。较低的波幅主要倾向于出现在一些有风险个体的亚组中，这些个体表现出一定程度的认知变化，这种变化由神经心理学测试标准定义。