Durham J, Steele J G, Breckons M, Story W, Vale L
Centre for Oral Health Research, Newcastle University, Newcastle-upon-Tyne, NE2 4BW, UK.
Institute of Health & Society, Newcastle University, Newcastle-upon-Tyne, UK.
J Oral Rehabil. 2015 Sep;42(9):643-50. doi: 10.1111/joor.12296. Epub 2015 Mar 30.
The EQ-5D-5L is a generic quality of life (QOL) measure widely used throughout the world, which has the advantage that it allows health-state preferences to be elicited. The aim of this study was to examine whether: a) variation in the standardised reference period for EQ-5D-5L from 'today' to 'the last month' had a minimal clinically meaningful difference; (b) EQ-5D-5L had convergent validity with a multidimensional pain measure in quantifying the impacts of pain. As part of a larger study into the effectiveness and efficiency of care pathways for persistent orofacial pain (POFP) (http://research.ncl.ac.uk/deepstudy), participants with POFP (n = 100) completed two versions of the EQ-5D-5L at the same time with different reference periods ('today' vs. 'last month'). Participants also completed the first section of the West Haven-Yale Multidimensional Pain Inventory (v3) to assess convergent validity. Two-tailed nonparametric inferential statistics, intra-class correlation coefficients (ICC), and within-subject change scores were used to compare the two EQ-5D-5L versions. Convergent validity was assessed using Spearman's rho correlation coefficients. Health-state valuations were significantly different (P < 0.01), and there was good similarity between the two versions' ICC 0.86 (95% CI 0.79-0.91). The within-subject mean change was 0.03 (95% CI 0.01-0.06). For convergent validity, all relationships were significant (P < 0.05) and in the expected directions. EQ-5D-5L demonstrates sufficient convergent validity to be used with POFP, and a change in the standard reference period may be unnecessary if a multidimensional pain measure is also used.
EQ-5D-5L是一种在全球广泛使用的通用生活质量（QOL）测量工具，其优点是能够得出健康状态偏好。本研究的目的是检验：a）EQ-5D-5L的标准化参考期从“今天”变为“过去一个月”是否存在最小临床意义差异；b）EQ-5D-5L在量化疼痛影响方面与多维疼痛测量工具是否具有收敛效度。作为一项关于持续性口面部疼痛（POFP）护理途径有效性和效率的更大规模研究（http://research.ncl.ac.uk/deepstudy）的一部分，POFP患者（n = 100）在同一时间完成了两个不同参考期（“今天”与“过去一个月”）的EQ-5D-5L版本。参与者还完成了西黑文-耶鲁多维疼痛量表（第3版）的第一部分以评估收敛效度。使用双尾非参数推断统计、组内相关系数（ICC）和受试者内变化分数来比较两个EQ-5D-5L版本。使用斯皮尔曼等级相关系数评估收敛效度。健康状态估值存在显著差异（P < 0.01），两个版本的ICC为0.86（95%CI 0.79 - 0.91），具有良好的相似性。受试者内平均变化为0.03（95%CI 0.01 - 0.06）。对于收敛效度，所有关系均显著（P < 0.05）且符合预期方向。EQ-5D-5L显示出足够的收敛效度可用于POFP，如果同时使用多维疼痛测量工具，可能无需改变标准参考期。
