Bedont Joseph L, Newman Elizabeth A, Blackshaw Seth
Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Wiley Interdiscip Rev Dev Biol. 2015 Sep-Oct;4(5):445-68. doi: 10.1002/wdev.187. Epub 2015 Mar 27.
Owing to its complex structure and highly diverse cell populations, the study of hypothalamic development has historically lagged behind that of other brain regions. However, in recent years, a greatly expanded understanding of hypothalamic gene expression during development has opened up new avenues of investigation. In this review, we synthesize existing work to present a holistic picture of hypothalamic development from early induction and patterning through nuclear specification and differentiation, with a particular emphasis on determination of cell fate. We will also touch on special topics in the field including the prosomere model, adult neurogenesis, and integration of migratory cells originating outside the hypothalamic neuroepithelium, and how these topics relate to our broader theme.
由于其结构复杂且细胞群体高度多样，下丘脑发育的研究在历史上一直落后于其他脑区。然而，近年来，对发育过程中下丘脑基因表达的深入了解开辟了新的研究途径。在这篇综述中，我们综合现有研究成果，呈现下丘脑从早期诱导和模式形成到核特化与分化的整体发育图景，特别强调细胞命运的决定。我们还将探讨该领域的一些特殊主题，包括前脑节模型、成体神经发生，以及源自下丘脑神经上皮之外的迁移细胞的整合，以及这些主题如何与我们的更广泛主题相关联。
