Walsh L J, Seymour G J, Powell R N
J Oral Pathol. 1985 Apr;14(4):315-21. doi: 10.1111/j.1600-0714.1985.tb00499.x.
The expression of the histocompatibility antigens HLA-DR and HLA-A, B, C within periodontally diseased tissue was investigated using immunohistological and histochemical techniques. Tissue was obtained from 18 patients with periodontal disease and from 2 healthy volunteers. HLA-DR antigen was expressed by the keratinocytes of the oral epithelium in all inflamed samples but was not a feature of normal tissue where HLA-DR reactivity was confined to Langerhans cells. These results are consistent with an underlying cellular immune process. Using a variety of phenotypic markers it was possible to characterize the macrophage population within the connective tissue into 2 distinct types: an antigen-presenting cell type located subjacent to the oral epithelium and a phagocytic cell type situated deep within the connective tissue.
采用免疫组织学和组织化学技术，研究了牙周病组织中组织相容性抗原HLA - DR以及HLA - A、B、C的表达情况。组织取自18例牙周病患者和2名健康志愿者。在所有炎症样本中，口腔上皮的角质形成细胞均表达HLA - DR抗原，但在正常组织中并非如此，正常组织中HLA - DR反应仅限于朗格汉斯细胞。这些结果与潜在的细胞免疫过程一致。利用多种表型标记物，可将结缔组织内的巨噬细胞群体分为2种不同类型：一种是位于口腔上皮下方的抗原呈递细胞类型，另一种是位于结缔组织深处的吞噬细胞类型。
