Park Bongki, You Sooseong, Jung Jeeyoun, Lee Ju Ah, Yun Kyung-Jin, Lee Myeong Soo
Medical Research Division, Korea Institute of Oriental Medicine, Daejeon 305-811, Republic of Korea.
Evid Based Complement Alternat Med. 2015;2015:316872. doi: 10.1155/2015/316872. Epub 2015 Mar 2.
Blood stasis is one of the important pathological concepts in Korean medicine. We analyzed the Korean studies concerning blood stasis. We searched for articles in eight electronic databases from their inception to September, 2014. We included reviews, clinical studies, and preclinical studies that had studied blood stasis and excluded articles in which blood stasis was not mentioned or in which the original authors had not explained blood stasis. Of 211 total included studies, 19 were reviews, 52 were clinical studies, and 140 were preclinical articles. "Stagnant blood within the body" was the most frequently mentioned phrase of the traditional concept of blood stasis. Traumatic injury was the most frequently studied disease/condition in the clinical studies. In the preclinical studies, coagulopathy was studied most frequently, followed by hyperviscosity, hyperlipidemia, inflammation, neoplasm, ischemic brain injury, and atherosclerosis. Hyeolbuchukeo-tang and Angelicae Gigantis Radix were the most frequent formula and single herb, respectively, used in the blood stasis researches. The results showed that blood stasis was mainly recognized as disorder of circulation and many studies showed the effectiveness of activating blood circulating herbs for diseases and pathologies such as traumatic injury or coagulopathy. Further studies are needed in the pathologic mechanisms and various diseases of blood stasis.
瘀血是韩医学中的重要病理概念之一。我们分析了有关瘀血的韩国研究。我们检索了八个电子数据库中从建库至2014年9月的文章。我们纳入了研究瘀血的综述、临床研究和临床前研究,并排除了未提及瘀血或原始作者未解释瘀血的文章。在总共纳入的211项研究中,19项为综述,52项为临床研究,140项为临床前文章。“体内瘀血”是传统瘀血概念中最常被提及的表述。创伤性损伤是临床研究中研究最频繁的疾病/状况。在临床前研究中,凝血障碍是研究最频繁的,其次是高粘血症、高脂血症、炎症、肿瘤、缺血性脑损伤和动脉粥样硬化。血府逐瘀汤和当归分别是瘀血研究中最常使用的方剂和单味药。结果表明,瘀血主要被认为是循环障碍,许多研究表明活血化瘀药对创伤性损伤或凝血障碍等疾病和病理状况有效。需要对瘀血的病理机制和各种疾病进行进一步研究。
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