González-Trujano María Eva, Pellicer Francisco, Mena Pedro, Moreno Diego A, García-Viguera Cristina
Laboratorio de Neurofarmacología de Productos Naturales, Dirección de Investigaciones en Neurociencias del Instituto Nacional de Psiquiatría Ramón de la Fuente , México, D. F. , México .
Int J Food Sci Nutr. 2015;66(4):395-9. doi: 10.3109/09637486.2015.1024208. Epub 2015 Mar 30.
Pomegranate (Punica granatum L.) has been used for centuries for the treatment of inflammatory diseases. However, there is a lack of comprehensive information focused on the properties of a certain pomegranate (poly)phenolic profile to cure pain and gastric injury induced by anti-inflammatory drugs. This study investigated the systemic effects of different doses of a HPLC-characterized pomegranate extract on the formalin-induced nociceptive behavior in mice. The effect of the extract against gastric injury caused by non-steroidal anti-inflammatory drugs and ethanol was also assessed. Pomegranate reduced nociception in both phases of the formalin test, suggesting central and peripheral activities to inhibit nociception. Indomethacin-induced gastric injury was not produced in the presence of pomegranate, which also protected against ethanol-induced gastric lesions. The present results reinforce the benefits of pomegranate (poly)phenolics in the treatment of pain as well as their anti-inflammatory properties.
几个世纪以来，石榴（Punica granatum L.）一直被用于治疗炎症性疾病。然而，目前缺乏关于特定石榴（多）酚类成分治疗抗炎药引起的疼痛和胃损伤特性的全面信息。本研究调查了不同剂量的经高效液相色谱法表征的石榴提取物对小鼠福尔马林诱导的伤害性反应行为的全身影响。还评估了该提取物对非甾体抗炎药和乙醇引起的胃损伤的作用。石榴在福尔马林试验的两个阶段均减轻了伤害性反应，表明其具有抑制伤害性反应的中枢和外周活性。在有石榴存在的情况下，未出现吲哚美辛诱导的胃损伤，石榴还能预防乙醇诱导的胃损伤。目前的结果进一步证明了石榴（多）酚类物质在治疗疼痛方面的益处及其抗炎特性。
