Department of Pharmacology .
Int J Food Sci Nutr. 2013 Nov;64(7):907-13. doi: 10.3109/09637486.2013.798268. Epub 2013 May 24.
In recent years, the therapeutic use of non-drug substances such as herbal and medicinal foods is increasing progressively. Of these substances, Punica granatum L., which is an ancient and highly distinctive fruit, has been proposed for treatment of several different illnesses. Ellagic acid (EA) is one of those biological molecules found in pomegranate and may have therapeutic potential in many diseases. EA has been detected not only in pomegranate but also in a wide variety of fruits and nuts such as raspberries, strawberries, walnuts, grapes and black currants, and is becoming an increasingly popular dietary supplement over recent years. Similar to other ellagitannins (ETs), EA is quite stable under physiological conditions in the stomach. EA and ETs as active agents induce vasorelaxation, oxygen free radical scavenging, hypolipidemic, anti-inflammatory and anti-carcinogenic activities in various animal preparations call an attention to the need for designing adequate tests in humans to assess these potentially useful properties in diseased states.
近年来，草药和药食同源物质等非药物物质的治疗用途逐渐增加。在这些物质中，石榴是一种古老而极具特色的水果，被提议用于治疗多种不同的疾病。鞣花酸（EA）是石榴中发现的一种生物分子，可能在许多疾病中具有治疗潜力。近年来，EA 不仅在石榴中被检测到，而且在各种水果和坚果如覆盆子、草莓、核桃、葡萄和黑加仑中也被检测到，它已成为一种越来越受欢迎的膳食补充剂。与其他鞣花单宁（ETs）一样，EA 在胃中的生理条件下相当稳定。EA 和 ETs 作为活性物质，在各种动物制剂中诱导血管舒张、清除氧自由基、降低血脂、抗炎和抗癌活性，这引起了人们的关注，需要在人体中设计足够的试验来评估这些在疾病状态下可能有用的特性。
