Wallow I, Johns K, Barry P, Chandra S, Bindley C
Ophthalmology. 1985 Apr;92(4):523-32. doi: 10.1016/s0161-6420(85)34012-5.
A patient with proliferative diabetic retinopathy was treated by panretinal and focal photocoagulation. Later, he developed one area of clinically diagnosed chorioretinal and choriovitreal neovascularization (CNV), neovascular glaucoma, and a blind painful eye necessitating enucleation. Clinicopathologic correlations of this eye including fundus photography, fluorescein angiography, light and electron microscopy are reported. Histopathologic examination revealed three areas of CNV, suggesting that some CNV may go undetected clinically also in other cases and thus may occur more frequently than evident from the literature. Our CNV occurred at sites of focal treatment. Retreatment of one area was unsuccessful. Choriovitreal neovascularization passed through discontinuities of Bruch's membrane into the retina and showed fenestrae of the endothelial cells. Endothelial fenestrae may account for the profuse fluorescein leakage seen clinically in CNV.
一名增殖性糖尿病视网膜病变患者接受了全视网膜和局部光凝治疗。后来，他出现了一个临床诊断为脉络膜视网膜和脉络膜玻璃体新生血管形成（CNV）的区域、新生血管性青光眼以及一只失明且疼痛的眼睛，需要进行眼球摘除术。报告了该眼的临床病理相关性，包括眼底照相、荧光素血管造影、光镜和电镜检查。组织病理学检查发现了三个CNV区域，提示在其他病例中一些CNV在临床上也可能未被检测到，因此其发生频率可能比文献中显示的更高。我们的CNV发生在局部治疗部位。对其中一个区域的再次治疗未成功。脉络膜玻璃体新生血管穿过布鲁赫膜的间断处进入视网膜，并显示出内皮细胞的窗孔。内皮窗孔可能是临床上CNV中所见大量荧光素渗漏的原因。
