专题综述：表观遗传学的新兴领域：为儿童创伤与身体健康模型提供信息
Topical Review: The Emerging Field of Epigenetics: Informing Models of Pediatric Trauma and Physical Health.
作者信息
Nugent Nicole R, Goldberg Amy, Uddin Monica
机构信息
Department of Psychiatry and Human Behavior, Warren Alpert Medical School at Brown University, Bradley Hasbro Research Center, Rhode Island Hospital,
Department of Pediatrics, Warren Alpert Medical School at Brown University, Lawrence A. Aubin Sr. Child Protection Center, Hasbro Children's Hospital and.
出版信息
J Pediatr Psychol. 2016 Jan-Feb;41(1):55-64. doi: 10.1093/jpepsy/jsv018. Epub 2015 Mar 29.
OBJECTIVE
Trauma experienced during childhood and adolescence has been linked to a number of chronic medical concerns. We highlight major findings from the pediatric trauma literature to provide a model for understanding this association.
METHODS
Studies examining the effects of trauma were systematically reviewed and synthesized into a model proposing a central role for epigenetics in the ways that childhood experiences can affect health.
RESULTS
Early hypothalamic pituitary adrenal (HPA) axis response may impact initial trauma experience, with downstream effects on posttrauma adjustment reflected in posttrauma neurobiology, psychological health, and physical health.
CONCLUSIONS
Prospective research with children and adolescents exposed to trauma is needed to better characterize the genetic and epigenetic influences on the course of HPA and immune processes as related to posttrauma psychological and physical health outcomes.
目的
童年和青少年时期经历的创伤与许多慢性医学问题有关。我们着重介绍儿科创伤文献的主要发现，以提供一个理解这种关联的模型。
方法
系统回顾了研究创伤影响的各项研究，并将其综合成一个模型，该模型提出表观遗传学在童年经历影响健康的方式中起核心作用。
结果
早期下丘脑-垂体-肾上腺（HPA）轴反应可能会影响最初的创伤经历，其下游效应在创伤后神经生物学、心理健康和身体健康方面的创伤后调整中得以体现。
结论
需要对遭受创伤的儿童和青少年进行前瞻性研究，以更好地描述与创伤后心理和身体健康结果相关的HPA和免疫过程中基因和表观遗传的影响。
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