酒精诱发胃食管反流
Induction of gastro-oesophageal reflux by alcohol.
作者信息
Kaufman S E, Kaye M D
出版信息
Gut. 1978 Apr;19(4):336-8. doi: 10.1136/gut.19.4.336.
Abstract
In order to establish whether alcohol in amounts in amounts customarily imbibed during social drinking causes gastro-oesophageal reflux, 12 healthy young individuals, without symptoms of gastro-oesophageal reflux, were studied twice. Each time, distal oesophageal pH was monitored continuously for three hours after a standard meal which included either 180 ml 100 proof vodka or 180 ml water. The order of studies with and without alcohol was random. Peak blood alcohol concentrations ranged between 0.63 and 1.29 g/l. Eleven of the 12 subjects refluxed more after alcohol; and the difference in mean reflux scores for studies with and without alcohol was highly significant. We conclude that relatively modest quanttities of alcohol induce gastro-oesophageal reflux in healthy people.
摘要
为了确定社交饮酒时通常饮用的酒精量是否会导致胃食管反流，对12名无胃食管反流症状的健康年轻人进行了两次研究。每次，在一顿标准餐后连续三小时持续监测食管远端pH值，这顿标准餐包含180毫升100度伏特加或180毫升水。饮酒和不饮酒研究的顺序是随机的。血液酒精浓度峰值在0.63至1.29克/升之间。12名受试者中有11名在饮酒后反流更多；饮酒和不饮酒研究的平均反流评分差异非常显著。我们得出结论，相对少量的酒精会在健康人群中诱发胃食管反流。
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