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丹麦全国性注册研究 16 年间确诊注意缺陷多动障碍发病率的时间趋势。

Time trends in incidence rates of diagnosed attention-deficit/hyperactivity disorder across 16 years in a nationwide Danish registry study.

机构信息

Research Unit of Child and Adolescent Psychiatry, Aalborg Psychiatric Hospital, Mølleparkvej 10, 9000 Aalborg, Denmark

出版信息

J Clin Psychiatry. 2015 Mar;76(3):e334-41. doi: 10.4088/JCP.14m09094.

DOI:10.4088/JCP.14m09094
PMID:25830455
Abstract

OBJECTIVE

To investigate time trends in incidence rates of first-time diagnosed attention-deficit/hyperactivity disorder (ADHD) in a nationwide sample aged 4-65 years across 16 years and identify potential contributing factors to these time trends.

METHOD

Incidence rates of first-time diagnosed ADHD based on ICD-10 criteria in Danish psychiatric hospitals per 100,000 person years (PY) were calculated for the total population, the 2 sexes, and 4 age groups using data from the Danish Psychiatric Central Research Registry and annual census data. Time trends and the role of contributing factors were analyzed and identified using joinpoint regression procedures by calculating annual percent changes for the time period 1995-2010.

RESULTS

A total of 20,281 patients were diagnosed with ADHD and incidence rates increased from 7.3 to 91.2 per 100,000 PY during the study period. Joinpoint analysis suggested that incidence rates for diagnosed ADHD rapidly increased from 1998 to 2002, peaked from 2002 to 2008, and slowed down from 2008 to 2010. Contributing factors to the observed time trends were a general increase in patients seen in psychiatry for any mental disorder and an increased awareness and recognition of ADHD in females, adolescents, and adults.

CONCLUSIONS

These results provide empirical data needed in the public and professional debate often based on theoretical rather than empirical arguments. Results support the notion of increasing incidence rates of diagnosed ADHD and identify that contributing factors are a general increase in the number of patients assessed in psychiatry and an increased recognition of females, adolescents, and adults with ADHD.

摘要

目的

在全国范围内,调查年龄在 4-65 岁的人群中首次被诊断为注意力缺陷多动障碍(ADHD)的发病率在 16 年间的时间趋势,并确定这些时间趋势的潜在影响因素。

方法

根据丹麦精神病医院基于 ICD-10 标准诊断的 ADHD 首次发病率,使用丹麦精神病中央研究登记处和年度人口普查数据,计算了总人口、男女两性和 4 个年龄组的每 10 万人年(PY)发病率。通过计算 1995-2010 年期间的年度百分比变化,使用连接点回归程序分析和确定时间趋势和影响因素的作用。

结果

共有 20281 例患者被诊断为 ADHD,发病率从 1995 年的 7.3 例/10 万 PY 增加到 2010 年的 91.2 例/10 万 PY。连接点分析表明,诊断为 ADHD 的发病率从 1998 年到 2002 年迅速上升,从 2002 年到 2008 年达到峰值,从 2008 年到 2010 年下降。观察到的时间趋势的影响因素是精神病学中任何精神障碍患者就诊人数的普遍增加,以及女性、青少年和成年人对 ADHD 的认识和认识的提高。

结论

这些结果提供了公共和专业辩论中经常基于理论而不是经验论据的必要实证数据。结果支持 ADHD 诊断发病率增加的观点,并确定了影响因素是精神病学评估患者人数的普遍增加以及对女性、青少年和成年人 ADHD 的认识提高。

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