2009年至2013年中国湖南省0至6岁儿童的血铅水平。
Blood lead levels in children aged 0-6 years old in Hunan Province, China from 2009-2013.
作者信息
Qiu Jun, Wang Kewei, Wu Xiaoli, Xiao Zhenghui, Lu Xiulan, Zhu Yimin, Zuo Chao, Yang Yongjia, Wang Youjie
机构信息
Department of Maternal and Child Health, School of Public Health, Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430030, China; Department of Children's Intensive Research Center, Hunan Children's Hospital, Changsha 410007, China.
Department of Children's Intensive Research Center, Hunan Children's Hospital, Changsha 410007, China.
出版信息
PLoS One. 2015 Apr 1;10(4):e0122710. doi: 10.1371/journal.pone.0122710. eCollection 2015.
OBJECTIVES
The aim of this study is to describe blood lead levels (BLLs) and the prevalence of elevated blood lead levels (EBLLs) in children aged 0-6 years old and to analyze the BLL trend in children from 2009 to 2013 in China.
METHODS
A total of 124,376 children aged 0-6 years old were recruited for this study from January 1st 2009 to December 31st 2013. Their blood lead levels were analyzed using atomic absorption spectrometry.
RESULTS
The median BLL was 64.3 μg/L (IQR: 49.6-81.0), and the range was 4.3-799.0 μg/L. Blood lead levels were significantly higher in boys (66.0 μg/L) than in girls (61.9 μg/L) (P<0.001). The overall prevalence of BLLs≥100 μg/L was 10.54% in children aged 0-6 years in Hunan Province. Between 2009 and 2013, the prevalence of EBLLs (≥100 μg/L) decreased from 18.31% to 4.26% in children aged 0-6 years and increased with age. The prevalence of EBLLs has dramatically decreased in two stages (2009-2010 and 2012-2013), with a slight fluctuation in 2010 and 2011.
CONCLUSIONS
Both BLLs and the prevalence of EBLLs in children aged 0-6 years old declined substantially from 2009 to 2013 in Hunan Province; however, both remain at unacceptably high levels compared to developed countries. Comprehensive strategies are required to further reduce blood lead levels in children.
目的
本研究旨在描述0至6岁儿童的血铅水平（BLLs）及血铅水平升高（EBLLs）的患病率，并分析2009年至2013年中国儿童的血铅水平趋势。
方法
2009年1月1日至2013年12月31日，共招募了124,376名0至6岁儿童参与本研究。采用原子吸收光谱法分析他们的血铅水平。
结果
血铅水平中位数为64.3μg/L（四分位间距：49.6 - 81.0），范围为4.3 - 799.0μg/L。男孩的血铅水平（66.0μg/L）显著高于女孩（61.9μg/L）（P<0.001）。湖南省0至6岁儿童血铅水平≥100μg/L的总体患病率为10.54%。2009年至2013年期间，0至6岁儿童血铅水平升高（≥100μg/L）的患病率从18.31%降至4.26%，且随年龄增长而升高。血铅水平升高的患病率在两个阶段（2009 - 2010年和2012 - 2013年）显著下降，2010年和2011年有轻微波动。
结论
2009年至2013年，湖南省0至6岁儿童的血铅水平和血铅水平升高的患病率均大幅下降；然而，与发达国家相比，两者仍处于不可接受的高水平。需要采取综合策略进一步降低儿童的血铅水平。
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