Department of Epidemiology, School of Public Health and Tropical Medicine, Southern Medical University, Guangzhou, China.
Gene. 2013 Jun 1;521(2):259-64. doi: 10.1016/j.gene.2013.03.073. Epub 2013 Mar 29.
Published data on the rs2910164 in microRNA-146a (miR-146a) are shown to be associated with increased or decreased autoimmune diseases risk. To derive a more precise estimation of the relationship, we performed a meta-analysis to systematically summarize the possible. A meta-analysis including 11 studies with 3042 controls and 2197 cases was performed for genotypes CC (recessive effect), CC+CG (dominant effect) and C allele in fixed or random-effects models based on between-study heterogeneity. Overall, no significant association between miR-146a G/C rs2910164 polymorphism and autoimmune diseases risk was found in all genetic models when all studies were pooled into the meta-analysis. SLE (OR=0.99, 95% CI: 0.90-1.10), RA (OR=0.98, 95% CI: 0.85-1.14) did not yield statistical significance as for C allele pooled studies. In the subgroup analysis by ethnicity, still no significant association was detected in all genetic models. Our meta-analysis suggests that there is no association between miR-146a G/C rs2910164 polymorphism and the development of autoimmune diseases.
已发表的数据表明，微 RNA-146a（miR-146a）中的 rs2910164 与自身免疫性疾病风险的增加或降低有关。为了更准确地评估这种关系，我们进行了荟萃分析以系统地总结可能的结果。我们对 11 项研究进行了荟萃分析，这些研究共包括 3042 名对照和 2197 名病例，采用固定或随机效应模型，基于研究间的异质性，对基因型 CC（隐性效应）、CC+CG（显性效应）和 C 等位基因进行分析。总体而言，当所有研究都纳入荟萃分析时，miR-146a G/C rs2910164 多态性与自身免疫性疾病风险之间在所有遗传模型中均无显著相关性。对于 C 等位基因合并研究，SLE（OR=0.99，95%CI：0.90-1.10）和 RA（OR=0.98，95%CI：0.85-1.14）也没有统计学意义。在按种族进行的亚组分析中，在所有遗传模型中均未发现显著相关性。我们的荟萃分析表明，miR-146a G/C rs2910164 多态性与自身免疫性疾病的发生之间没有关联。
