氯仿改变脂质双层中的小叶间耦合：一种熵机制。
Chloroform alters interleaflet coupling in lipid bilayers: an entropic mechanism.
作者信息
Reigada Ramon, Sagués Francesc
机构信息
Departament de Quimica Fisica and Institut de Quimica Teorica i Computacional (IQTCUB), Universitat de Barcelona, c/Martí i Franquès 1, Pta. 4, 08028 Barcelona, Spain
Departament de Quimica Fisica and Institut de Nanociencia i Nanotecnologia (IN2UB), Universitat de Barcelona, c/Martı́ i Franquès 1, Pta. 4, 08028 Barcelona, Spain.
出版信息
J R Soc Interface. 2015 May 6;12(106). doi: 10.1098/rsif.2015.0197.
Abstract
The interaction of the two leaflets of the plasmatic cell membrane is conjectured to play an important role in many cell processes. Experimental and computational studies have investigated the mechanisms that modulate the interaction between the two membrane leaflets. Here, by means of coarse-grained molecular dynamics simulations, we show that the addition of a small and polar compound such as chloroform alters interleaflet coupling by promoting domain registration. This is interpreted in terms of an entropic gain that would favour frequent chloroform commuting between the two leaflets. The implication of this effect is discussed in relation to the general anaesthetic action.
摘要
推测质膜的两个小叶之间的相互作用在许多细胞过程中发挥重要作用。实验和计算研究已经探究了调节两个膜小叶之间相互作用的机制。在此，我们通过粗粒度分子动力学模拟表明，添加一种小的极性化合物（如氯仿）会通过促进结构域配准来改变小叶间的耦合。这可以用熵增来解释，熵增有利于氯仿在两个小叶之间频繁交换。我们结合全身麻醉作用讨论了这种效应的影响。
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2
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Biophys J. 2014 Nov 18;107(10):2296-304. doi: 10.1016/j.bpj.2014.10.016.
3
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