通过分析胆汁酸内稳态失衡来解释结肠癌的病理生理学
Explanation of colon cancer pathophysiology through analyzing the disrupted homeostasis of bile acids.
作者信息
Dongfeng Duan, An Chen, Shujia Peng, Jikai Yin, Tao Yang, Rui Dong, Kai Tan, Yafeng Chen, Jianguo Lu, Xilin Du
机构信息
Department of general surgery, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, PR China.
出版信息
Afr Health Sci. 2014 Dec;14(4):925-8. doi: 10.4314/ahs.v14i4.22.
Abstract
BACKGROUND
The colon plays a key role in regulating the homeostasis of bile acids.
AIM
The present study aims to evaluate the influence of colon cancer towards the homeostasis of bile acids.
METHODS
The free and conjugated bile acids were determined using ultraperformance LC (UPLC) coupled with ABI 4000 QTRAP triple quadrupole instruments.
RESULTS
The results showed that the free bile acids in serum of patients with colon cancers tend to increase, and the conjugated bile acids tended to decrease, especially for taurolithocholate (TLCA) (p<0.001).
CONCLUSION
The alteration of bile acids balance in colon cancers indicated the possibility of complicated diseases due to the disrupted balance of bile acids.
摘要
背景
结肠在调节胆汁酸的稳态中起关键作用。
目的
本研究旨在评估结肠癌对胆汁酸稳态的影响。
方法
使用超高效液相色谱（UPLC）结合ABI 4000 QTRAP三重四极杆仪器测定游离和结合胆汁酸。
结果
结果显示，结肠癌患者血清中的游离胆汁酸趋于增加，而结合胆汁酸趋于减少，尤其是牛磺石胆酸（TLCA）（p<0.001）。
结论
结肠癌中胆汁酸平衡的改变表明由于胆汁酸平衡紊乱导致复杂疾病的可能性。
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Editorial.社论
Afr Health Sci. 2014 Dec;14(4):i-iii. doi: 10.4314/ahs.v14i4.1.
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