台湾肺炎克雷伯菌中主要国际高风险耐药克隆和毒力克隆与特定ompK36等位基因组的关联。
Associations of the major international high-risk resistant clones and virulent clones with specific ompK36 allele groups in Klebsiella pneumoniae in Taiwan.
作者信息
Yan J J, Wang M C, Zheng P X, Tsai L H, Wu J J
机构信息
Department of Pathology, National Cheng Kung University College of Medicine and Hospital, Taiwan.
Department of Internal Medicine, National Cheng Kung University College of Medicine and Hospital, Taiwan.
出版信息
New Microbes New Infect. 2015 Feb 9;5:1-4. doi: 10.1016/j.nmni.2015.01.002. eCollection 2015 May.
This study was conducted to investigate the association between ompK36 variants and international high-risk clones in Klebsiella pneumoniae. Fifty-nine sequence types (STs) divided into four ompK36 allele groups (groups A to D) were identified among 185 K. pneumoniae isolates. The major high-risk clones (29 ST11, 13 ST15, 7 ST37 and 1 ST147 isolates) were assigned to group A, while 6 STs (15 ST23, 2 ST65, 3 ST86, 1 ST163, 1 ST373 and 2 ST375 isolates) associated with pyogenic liver abscess were assigned to group C. The genotyping assay developed in this study may be useful for screening of epidemic STs.
本研究旨在调查肺炎克雷伯菌中ompK36变异体与国际高风险克隆之间的关联。在185株肺炎克雷伯菌分离株中，鉴定出59种序列类型（STs），分为4个ompK36等位基因组（A组至D组）。主要的高风险克隆（29株ST11、13株ST15、7株ST37和1株ST147分离株）被归为A组，而与化脓性肝脓肿相关的6种STs（15株ST23、2株ST65、3株ST86、1株ST163、1株ST373和2株ST375分离株）被归为C组。本研究开发的基因分型检测方法可能有助于筛查流行的STs。
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