Blin Juliana, Fitzgerald Katherine A
Département de Biologie, École Normale Supérieure de Lyon, Lyon, France; Program in Innate Immunity, Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.
Program in Innate Immunity, Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.
Cytokine. 2015 Aug;74(2):175-80. doi: 10.1016/j.cyto.2015.03.005. Epub 2015 Mar 30.
The RNA exosome is a highly conserved exoribonuclease complex that is involved in RNA processing, quality control and turnover regulation. The exosome plays pleiotropic functions by recruiting different cofactors that regulate its target specificity. Recently, the exosome has been implicated in the regulation of immune processes including cytokine production and negative regulation of innate sensing of nucleic acids. Careful regulation of such mechanisms is critical to avoid a breakdown of self-tolerance and the pathogenesis of autoimmune disorders. This perspective briefly introduces the exosome, its its normal function in RNA biology and summarizes regulatory roles of the RNA exosome in immunity. Finally we discuss how dysregulation of exosome function can lead to autoimmune disease.
RNA外切体是一种高度保守的外切核糖核酸酶复合体，参与RNA加工、质量控制和周转调节。外切体通过招募不同的辅因子来调节其靶标特异性，从而发挥多效性功能。最近，外切体已被证明参与免疫过程的调节，包括细胞因子的产生和对核酸天然免疫传感的负调节。对这些机制进行精细调节对于避免自身耐受性的破坏和自身免疫性疾病的发病机制至关重要。本综述简要介绍了外切体及其在RNA生物学中的正常功能，并总结了RNA外切体在免疫中的调节作用。最后，我们讨论了外切体功能失调如何导致自身免疫性疾病。
