Dolgan Anna, Budrewicz Slawomir, Koszewicz Magdalena, Bladowska Joanna, Slotwinski Krzysztof, Zagrajek Mieszko, Koziorowska-Gawron Ewa, Podemski Ryszard
From the Department of Neurology (AD, SB, MK, KS, MZ, EK-G, RP), and Department of General Radiology, Interventional Radiology and Neuroradiology (BJ), Wroclaw Medical University, Borowska, Wroclaw, Poland.
J Addict Med. 2015 May-Jun;9(3):244-5. doi: 10.1097/ADM.0000000000000048.
A new form of manganese poisoning is related to the intravenous use of self-prepared methcathinone hydrochloride (ephedrone). Manganese encephalopathy typically manifests as a levodopa-resistant parkinsonism.
A 32-year-old drug-addicted man with acute gait disturbances after the ephedrone injections was presented. Choreic movements, severe postural instability, and "cock-walk" gait were observed. Magnetic resonance imaging T1 images showed high signal intensity of white matter in the basal ganglia and pituitary gland, and T2 images showed decreased signal mostly of globus pallidus with decreased N-acetylaspartate and choline levels in MR spectroscopy.
The unusual pattern of MR imaging may explain the unusual clinical symptoms with dominant hyperkinetic syndrome.
一种新型锰中毒与静脉注射自制盐酸甲卡西酮（麻黄酮）有关。锰脑病通常表现为左旋多巴抵抗性帕金森综合征。
报告一名32岁的吸毒成瘾男子，在注射麻黄酮后出现急性步态障碍。观察到舞蹈样动作、严重姿势不稳和“公鸡步”步态。磁共振成像T1图像显示基底节和垂体白质高信号强度，T2图像显示苍白球信号大多降低，磁共振波谱显示N-乙酰天门冬氨酸和胆碱水平降低。
磁共振成像的异常表现可能解释以多动综合征为主的异常临床症状。
