Bayne Kathryn, Ramachandra Gudde S, Rivera Ekaterina A, Wang Jianfei
Association for Assessment and Accreditation of Laboratory Animal Care International, Frederick, Maryland, USA.
Indian Institute of Science, Bangalore, Karnataka, India.
J Am Assoc Lab Anim Sci. 2015 Mar;54(2):181-91.
Increasingly, scientific collaborations and contracts cross country borders. The need for assurance that the quality of animal welfare and the caliber of animal research conducted are equivalent among research partners around the globe is of concern to the scientific and laboratory animal medicine communities, the general public, and other key stakeholders. Therefore, global harmonization of animal care and use standards and practices, with the welfare of the animals as a cornerstone, is essential. In the evolving global landscape of enhanced attention to animal welfare, a widely accepted path to achieving this goal is the successful integration of the 3Rs in animal care and use programs. Currently, awareness of the 3Rs, their implementation, and the resulting animal care and use standards and practices vary across countries. This variability has direct effects on the animals used in research and potentially the data generated and may also have secondary effects on the country's ability to be viewed as a global research partner. Here we review the status of implementation of the 3Rs worldwide and focus on 3 countries-Brazil, China and India-with increasing economic influence and an increasing footprint in the biomedical research enterprise.
科学合作与合同越来越多地跨越国界。确保全球研究伙伴之间动物福利质量和动物研究水平相当的需求，受到科学界、实验动物医学界、公众及其他关键利益相关者的关注。因此，以动物福利为基石，实现动物护理和使用标准及做法的全球协调至关重要。在日益重视动物福利的全球格局中，实现这一目标的一条广泛接受的途径是在动物护理和使用计划中成功整合“3R”原则。目前，各国对“3R”原则的认识、其实施情况以及由此产生的动物护理和使用标准及做法各不相同。这种差异对研究中使用的动物有直接影响，可能也会影响所产生的数据，还可能对该国作为全球研究伙伴的形象产生间接影响。在此，我们综述全球“3R”原则的实施现状，并重点关注巴西、中国和印度这三个国家，它们在生物医学研究领域的经济影响力不断增强，影响力不断扩大。
