Group of Molecular Neurobiology, Division of Biological Science, Graduate School of Science, Nagoya University, Nagoya 464-8602, Japan.
Group of Molecular Neurobiology, Division of Biological Science, Graduate School of Science, Nagoya University, Nagoya 464-8602, Japan.
Curr Opin Neurobiol. 2015 Oct;34:117-24. doi: 10.1016/j.conb.2015.03.011. Epub 2015 Mar 31.
As the environmental temperature prominently influences diverse biological aspects of the animals, thermosensation and the subsequent information processing in the nervous system has attracted much attention in biology. Thermotaxis in the nematode Caenorhabditis elegans is an ideal behavioral paradigm by which to address the molecular mechanism underlying thermosensory transduction. Molecular genetic analysis in combination with other physiological and behavioral studies revealed that sensation of ambient temperature is mediated mainly by cyclic guanosine monophosphate (cGMP) signaling in thermosensory neurons. The information of the previously perceived temperature is also stored within the thermosensory neurons, and the consequence of the comparison between the past and the present temperature is conveyed to the downstream interneurons to further regulate the motor-circuits that encode the locomotion.
由于环境温度显著影响动物的多种生物学特性，因此神经系统中的热感觉及其随后的信息处理在生物学中受到了广泛关注。秀丽隐杆线虫的趋温性是研究热感觉转导分子机制的理想行为范例。通过分子遗传学分析结合其他生理学和行为学研究表明，环境温度的感觉主要是通过热敏神经元中环鸟苷酸单磷酸（cGMP）信号转导来介导的。热敏神经元内还存储了之前感知到的温度信息，并且过去和现在温度之间的差异信息被传递到下游中间神经元，以进一步调节编码运动的运动回路。
