Hope P G, Kristinsson K G, Norman P, Elson R A
Northern General Hospital, Sheffield, England.
J Bone Joint Surg Br. 1989 Nov;71(5):851-5. doi: 10.1302/0301-620X.71B5.2584258.
We reviewed a series of 91 patients with deep infection of a cemented total hip arthroplasty caused by coagulase-negative staphylococci (C-NS). Of these, 72 were treated by one-stage exchange arthroplasty with a failure rate of 13% due to recurrence of infection. The other 19 patients have started or completed treatment by a two-stage exchange without failure to date. In 27 of the 91 patients multiple strains of C-NS were discovered, many being resistant to previously used antibiotics. The use of gentamicin-containing cement in the primary arthroplasty was significantly associated with the emergence of gentamicin-resistant C-NS in subsequent deep infection. Bacteriological diagnosis of such infections must take into consideration the possibility that multiple strains of the organism are involved.
我们回顾了一系列91例由凝固酶阴性葡萄球菌（C-NS）引起的骨水泥型全髋关节置换术后深部感染的患者。其中，72例接受了一期翻修置换术，因感染复发，失败率为13%。另外19例患者已开始或完成了两期翻修治疗，至今无失败病例。在91例患者中的27例发现了多种C-NS菌株，许多菌株对先前使用的抗生素耐药。初次关节置换术中使用含庆大霉素的骨水泥与随后深部感染中出现庆大霉素耐药的C-NS显著相关。对此类感染的细菌学诊断必须考虑到涉及多种菌株的可能性。
