Dodson Paul D, Larvin Joseph T, Duffell James M, Garas Farid N, Doig Natalie M, Kessaris Nicoletta, Duguid Ian C, Bogacz Rafal, Butt Simon J B, Magill Peter J
Medical Research Council Brain Network Dynamics Unit, Department of Pharmacology, University of Oxford, Oxford OX1 3QT, UK; Oxford Parkinson's Disease Centre, University of Oxford, Oxford OX1 3QX, UK.
Medical Research Council Brain Network Dynamics Unit, Department of Pharmacology, University of Oxford, Oxford OX1 3QT, UK.
Neuron. 2015 Apr 22;86(2):501-13. doi: 10.1016/j.neuron.2015.03.007. Epub 2015 Apr 2.
Transcriptional codes initiated during brain development are ultimately realized in adulthood as distinct cell types performing specialized roles in behavior. Focusing on the mouse external globus pallidus (GPe), we demonstrate that the potential contributions of two GABAergic GPe cell types to voluntary action are fated from early life to be distinct. Prototypic GPe neurons derive from the medial ganglionic eminence of the embryonic subpallium and express the transcription factor Nkx2-1. These neurons fire at high rates during alert rest, and encode movements through heterogeneous firing rate changes, with many neurons decreasing their activity. In contrast, arkypallidal GPe neurons originate from lateral/caudal ganglionic eminences, express the transcription factor FoxP2, fire at low rates during rest, and encode movements with robust increases in firing. We conclude that developmental diversity positions prototypic and arkypallidal neurons to fulfil distinct roles in behavior via their disparate regulation of GABA release onto different basal ganglia targets.
在大脑发育过程中启动的转录编码最终在成年期表现为不同的细胞类型，这些细胞类型在行为中发挥着特殊作用。以小鼠外侧苍白球（GPe）为研究对象，我们证明了两种GABA能GPe细胞类型对自主行为的潜在贡献从早期生命起就注定不同。典型的GPe神经元起源于胚胎期皮质下内侧神经节隆起，并表达转录因子Nkx2-1。这些神经元在警觉休息时高频放电，并通过异质性放电频率变化编码运动，许多神经元会降低其活动。相比之下，苍白球GPe神经元起源于外侧/尾侧神经节隆起，表达转录因子FoxP2，在休息时低频放电，并通过放电的强烈增加来编码运动。我们得出结论，发育多样性使典型神经元和苍白球神经元通过对不同基底神经节靶点释放GABA的不同调节，在行为中发挥不同作用。
