Ungprasert Patompong, Srivali Narat, Kittanamongkolchai Wonngarm
a Division of Rheumatology, Mayo Clinic , Rochester , MN , USA.
b Division of Rheumatology, Department of Internal Medicine , Faculty of Medicine Siriraj Hospital, Mahidol university , Bangkok , Thailand.
Mod Rheumatol. 2015 Nov;25(6):893-897. doi: 10.3109/14397595.2015.1038456. Epub 2015 May 28.
Several chronic inflammatory disorders, such as rheumatoid arthritis, inflammatory myositis, and systemic vasculitides, have been linked to an increased risk of venous thromboembolism (VTE). However, the data on systemic sclerosis (SSc) remains unclear.
We conducted a systematic review and meta-analysis of observational studies that reported odds ratio, relative risk, hazard ratio, or standardized incidence ratio comparing risk of VTE in patients with SSc versus non-SSc participants. Pooled risk ratio and 95% confidence intervals (CIs) were calculated using a random-effect, generic inverse variance method of DerSimonian and Laird.
Out of 776 potentially relevant articles, five eligible studies were identified and included in the data analysis. The pooled risk ratio of VTE in patients with SSc was 2.51 (95% CI, 1.79-3.54). The statistical heterogeneity of this study was high with an I of 90%.
Our study demonstrated a statistically significant increased VTE risk among patients with SSc.
几种慢性炎症性疾病，如类风湿性关节炎、炎性肌病和系统性血管炎，与静脉血栓栓塞（VTE）风险增加有关。然而，关于系统性硬化症（SSc）的数据仍不明确。
我们对观察性研究进行了系统评价和荟萃分析，这些研究报告了比较SSc患者与非SSc参与者VTE风险的比值比、相对风险、风险比或标准化发病率比。采用DerSimonian和Laird的随机效应、通用逆方差法计算合并风险比和95%置信区间（CI）。
在776篇潜在相关文章中，确定了5项符合条件的研究并纳入数据分析。SSc患者VTE的合并风险比为2.51（95%CI，1.79 - 3.54）。本研究的统计异质性较高，I²为90%。
我们的研究表明，SSc患者的VTE风险在统计学上显著增加。
