Purvey S, Lu K, Mukkamalla S K, Anandi P, Dumitriu B, Kranick S, Hammoud D A, O'Connell E, Oh A L, Barrett J, Mahanty S, Battiwalla M
Hematology Branch, National Heart, Lung, Blood Institute, National Institutes of Health (NIH), Bethesda, Maryland, USA.
National Institute of Neurological Disorders and Stroke, NIH, Bethesda, Maryland, USA.
Transpl Infect Dis. 2015 Jun;17(3):456-62. doi: 10.1111/tid.12392. Epub 2015 Jun 1.
Neurocysticercosis, an infection of the central nervous system with the larval stage of the cestode Taenia solium, is common in developing countries but its occurrence and management in allogeneic hematopoietic stem cell transplantation (HSCT) has not been reported previously, to our knowledge. We report the case of an immigrant female patient who underwent a matched-related allogeneic HSCT for acute lymphoblastic leukemia and was incidentally found to have a solitary viable neurocysticercosis lesion. However, despite severe immunosuppression, the size of the cyst did not increase. More importantly, restoration of the immune system did not induce significant inflammation or seizures. Subsequent follow-up demonstrated complete resolution of the neurocysticercosis lesion. Thus, in the setting of HSCT, an asymptomatic patient with a single neurocysticercosis lesion was successfully managed without the use of anthelmintics, steroids, or anti-epileptics.
神经囊尾蚴病是由绦虫猪带绦虫的幼虫阶段感染中枢神经系统引起的,在发展中国家很常见,但据我们所知,其在异基因造血干细胞移植(HSCT)中的发生情况和管理此前尚未见报道。我们报告了一例移民女性患者,她因急性淋巴细胞白血病接受了匹配相关的异基因HSCT,偶然发现有一个孤立的存活神经囊尾蚴病病灶。然而,尽管存在严重的免疫抑制,囊肿大小并未增加。更重要的是,免疫系统的恢复并未引发明显的炎症或癫痫发作。随后的随访显示神经囊尾蚴病病灶完全消退。因此,在HSCT的情况下,一名患有单个神经囊尾蚴病病灶的无症状患者在未使用驱虫药、类固醇或抗癫痫药的情况下得到了成功治疗。