Boyd S K, Burt L A, Sevick L K, Hanley D A
McCaig Institute for Bone and Joint Health, University of Calgary, 3280 Hospital Drive, NW, Calgary, Alberta, T2N 4Z6, Canada,
Osteoporos Int. 2015 Sep;26(9):2375-80. doi: 10.1007/s00198-015-3110-5. Epub 2015 Apr 8.
The relation between serum 25-hydroxy vitamin D [25(OH)D] and bone quality is not well understood, particularly for high levels. We measured bone microarchitecture in three groups of people stratified by their serum 25(OH)D. There was a weak association of serum 25(OH)D and microarchitecture for this cross-sectional population, suggesting possible benefits to bone quality.
Vitamin D plays an important role in bone and mineral metabolism, but the relation between serum 25(OH)D and bone quality is not well understood. Here, we present a cross-sectional study that investigated a convenience group of participants from an ongoing health initiative in Alberta, Canada, who have been receiving daily vitamin D supplementation.
A total of 105 participants were organized into three groups based on their serum 25(OH)D levels: low (<75 nmol/L), medium (75-175 nmol/L), and high (>175 nmol/L). They were also assessed with 25(OH)D as a continuous variable. Average daily supplementation was 7670 ± 438 IU, and the change in 25(OH)D ranged from 22 to 33 % during the period of receiving supplements. We used high-resolution peripheral quantitative computed tomography measurements at the radius and tibia to assess bone microarchitecture.
Microarchitectural parameters were not strongly associated with serum 25(OH)D. In the tibia, there were fewer trabeculae (TbN; p = 0.015) and a non-significant trend toward thicker trabeculae (p = 0.067) of the high group. Body mass index (BMI) was negatively associated with serum 25(OH)D levels (p < 0.001) and PTH levels (p < 0.001). There was no clinically significant relationship detected between high serum 25(OH)D and high serum calcium.
These data suggest a weak relationship between serum 25(OH)D and bone microarchitecture in this population of mostly vitamin-D-sufficient participants, and there were no indications of negative effects related to the high supplementation levels. These data provided a basis to design and implement our 3-year dose-dependent randomized controlled trial investigating the effects of vitamin D supplementation on bone health outcomes.
血清25-羟基维生素D[25(OH)D]与骨质量之间的关系尚未完全明确，尤其是在其高水平时。我们对三组根据血清25(OH)D分层的人群的骨微结构进行了测量。对于这个横断面人群，血清25(OH)D与微结构之间存在微弱关联，提示对骨质量可能有益。
维生素D在骨骼和矿物质代谢中起重要作用，但血清25(OH)D与骨质量之间的关系尚未完全明确。在此，我们开展了一项横断面研究，调查了来自加拿大艾伯塔省一项正在进行的健康倡议中的一组便利样本参与者，他们一直在接受每日维生素D补充。
根据血清25(OH)D水平将总共105名参与者分为三组：低水平组(<75 nmol/L)、中等水平组(75 - 175 nmol/L)和高水平组(>175 nmol/L)。他们还将25(OH)D作为连续变量进行评估。平均每日补充量为7670±438 IU，在接受补充剂期间25(OH)D的变化范围为22%至33%。我们使用高分辨率外周定量计算机断层扫描测量桡骨和胫骨的骨微结构。
微结构参数与血清25(OH)D没有强烈关联。在胫骨中，高水平组的小梁数量较少(TbN；p = 0.015)，小梁有增厚的趋势但不显著(p = 0.067)。体重指数(BMI)与血清25(OH)D水平呈负相关(p < 0.001)，与甲状旁腺激素水平呈负相关(p < 0.001)。未检测到高血清25(OH)D与高血清钙之间存在具有临床意义的关系。
这些数据表明在这个大多维生素D充足的人群中，血清25(OH)D与骨微结构之间存在微弱关系，并且没有迹象表明高补充水平会产生负面影响。这些数据为设计和实施我们为期3年的剂量依赖性随机对照试验提供了依据，该试验旨在研究维生素D补充对骨骼健康结局的影响。
